Investigating the interplay of smoking, cardiovascular risk factors, and overall cardiovascular disease risk: NHANES analysis 2011–2018

• DOI: 10.1186/s12872-024-03838-7
• Publication Date: 2024-04-04T08:02:27Z
• Authors: Athumani Mambo; Yulu Yang; Emmerenceana Mahulu; Zhou Zihua
• Keywords: Quartile; Dyslipidemia

Abstract Background This study explores the intricate relationship between smoking, cardiovascular disease (CVD) risk factors and their combined impact on overall CVD risk, utilizing data from NHANES 2011–2018. Methods Participants were categorized based presence of CVD, we compared demographic, social, clinical characteristics. We utilized logistic regression models, receiver operating characteristics (ROC) analysis, chi-squared test to examine associations variables risk. Results Significant differences in observed those with without CVD. Serum cotinine levels exhibited a dose-dependent association The highest quartile corresponded 2.33-fold increase Smoking, especially conjunction lower HDL-c, significantly increases Combinations smoking hypertension, central obesity, diabetes, elevated triglycerides also contributed increased Waist-to-Height Ratio, Visceral Adiposity Index, A Body Shape Conicity Triglyceride-Glucose Neutrophil, Mean platelet volume Neutrophil Lymphocyte ratio demonstrated significant varying significance post-adjustment. When assessing effect multiple factors, combination higher triglycerides, hypertension presented an adjusted odds 14.18. Conclusion when