Assessing repeatability and reproducibility of Anterior Active Rhinomanometry (AAR) in children

• DOI: 10.1186/s12874-020-00969-1
• Publication Date: 2020-04-17T05:02:24Z
• Authors: Giovanna Cilluffo; Anna Maria Zicari; Giuliana Ferrante; Velia Malizia; Salvatore Fasola; Marzia Duse; Giovanna De Castro; Valentina De Vittori; Laura Schiavi; Giulia Brindisi; Paolo Petrelli; Stefania La Grutta
• Keywords: Repeatability; Rhinomanometry; Coefficient of variation

Abstract Background Repeatability and reproducibility are essential for clinicians several purposes. Although discouraged, use of the Coefficient Variation (CV) assessing repeatability reproducibility, rather than Intraclass Correlation (ICC), is still widespread. The aim present study was to highlight how using inappropriate indices may lead misleading results, this done by simulation real data on Anterior Active Rhinomanometry (AAR) in both healthy children ones with rhinitis. Methods A carried out could be misleading. Then a comparison made between CV ICC assess AAR, which previous studies have given underestimated results. AAR recommended as gold standard tool measuring nasal resistance clinical practice. Results showed that ICCs estimated from generated assuming true yielded results agreement CVs; contrast, if were ICC, CVs conflicting For good repeatability, whereas unacceptable repeatability. AUC 95% CI performance predicting current symptoms rhinitis overall population. Conclusions focused importance choice appropriate demonstrating Trial registration ClinicalTrials.gov (ID: NCT03286049 ; Registration Date: September 15, 2017; Actual Study Start January 10, 2018).