Sex and ethnic/racial-specific risk factors for gallbladder disease

• DOI: 10.1186/s12876-017-0678-6
• Publication Date: 2017-12-08T12:00:24Z
• Authors: Jane C. Figueiredo; Christopher Haiman; Jacqueline Porcel; James Buxbaum; Daniel Stram; Neal Tambe; Wendy Cozen; Lynne Wilkens; Loic Le Marchand; Veronica Wendy Se...
• Keywords: Gallbladder disease; Red meat

Gallbladder disease (GBD) is a highly prevalent condition; however, little known about potential differences in risk factors by sex and ethnicity/race. Our aim was to evaluate dietary, reproductive obesity-related GBD multiethnic populations.We performed prospective analysis from the Multiethnic Cohort study who self-identified as non-Hispanic White (n = 32,103), African American 30,209), Japanese 35,987), Native Hawaiian 6942) Latino 39,168). cases were identified using Medicare California hospital discharge files (1993-2012) self-completed questionnaires. We used exposure information on baseline questionnaire identify exposures of interest. Associations estimated hazard ratios 95% confidence intervals Cox models adjusted for confounders.After median 10.7 years follow-up, there 13,437 cases. BMI over 25 kg/m2, diabetes, past current smoking, red meat consumption, saturated fat cholesterol significant across ethnic/racial populations (p-trends < 0.01). Protective included vigorous physical activity, alcohol use, fruits, vegetables foods rich dietary fiber Carbohydrates inversely associated with only among women Latinos born South America/Mexico (p-trend 0.003). Parity factor women; post-menopausal hormones use an increased (estrogen-only: HR 1.24; CI 1.07-1.43 estrogen + progesterone: 1.23; 1.06-1.42).Overall, are strong affecting men different ethnicities/races; however some appear stronger certain ethnic groups.