Nomogram for predicting overall survival in colorectal cancer with distant metastasis

• DOI: 10.1186/s12876-021-01692-x
• Publication Date: 2021-03-04T19:02:53Z
• Authors: Zheng Liu; Yao Xu; Guijun Xu; Vladimir P. Bakla...; Vladimir P. Chekh...; Karl Peltzer; Wenjuan Ma; Xin Wang; Guowen Wang; Chao Zhang
• Keywords: Nomogram; Prognostic variable

Abstract Background Colorectal cancer (CRC) is a major burden, and prognosis determined by many demographic clinicopathologic factors. The present study aimed to construct prognostic nomogram for colorectal patients with distant metastasis. Methods metastasis diagnosed between 2010 2016 were selected from the Surveillance, Epidemiology, End Results database. Cox proportional hazards regression was used identify independent A constructed predict survival, validation performed. total of 7099 stage IV enrolled in construction cohort. median overall survival 20.0 (95% CI 19.3–20.7) months. Age at diagnosis, marital status, race, primary tumour site, grade, CEA level, T stage, N presence bone, brain, liver lung metastasis, surgery site performance chemotherapy calibration curve showed satisfactory agreement. C-index 0.742 0.726–0.758). In cohort (7098 patients), discrimination 0.746 0.730–0.762). Conclusion series factors associated CRC found. Based on identified factors, generated patients. predictive model calibration, which can provide reference estimation individualized treatment decisions.