Total polyunsaturated fatty acid intake and the risk of non-alcoholic fatty liver disease in Chinese Han adults: a secondary analysis based on a case–control study

• DOI: 10.1186/s12876-021-02039-2
• Publication Date: 2021-11-30T19:25:23Z
• Authors: Yong Xie; Huan Tian; Bin Xiang; Ding Li; Jian Liu; Zhuoyan Cai; Yuzhou Liu; Hua Xiang
• Keywords: Risk; Adult; 0301 basic medicine; 2. Zero hunger; 0303 health sciences; Case–control study; Research; RC799-869; Diseases of the digestive system. Gastroenterology; Diet; 3. Good health; 03 medical and health sciences; Polyunsaturated fatty acid; Cross-Sectional Studies; Non-alcoholic Fatty Liver Disease; Risk Factors; Case-Control Studies; Fatty Acids, Unsaturated; Humans; Non-alcoholic fatty liver disease; Secondary analysis; Retrospective Studies

AbstractBackgroundPrevious studies have revealed obesity, nutrition, lifestyle, genetic and epigenetic factors may be risk factors for the occurrence and development of non-alcoholic fatty liver disease (NAFLD). However, the effect of total polyunsaturated fatty acid (PUFA) consumption on the risk of NAFLD is uncertain. Therefore, this study aimed to determine whether the total PUFA intake is independently associated with the risk of NAFLD and explore the threshold of PUFA intake better illustrate the correlation between them in Chinese Han adults.MethodsThe present study was a retrospective case–control study. A total of 534 NAFLD patients and 534 controls matched by gender and age in the same center were included in this study. Using a semi-quantitative food frequency questionnaire in a health examination center in China to collect information about dietary intake and calculate nutrient consumption. A multivariate logistic regression model was used to estimate the association between total PUFA daily intake and its quartile and the incidence of NAFLD.ResultsMultivariate analyses suggested a significant association between total PUFA intake and the occurrence of NAFLD. A non-linear relationship between total PUFA consumption and NAFLD risk was detected after adjusting for potential confounding factors. There was a significant connection between PUFA and the risk of NAFLD (OR: 1.32, 95% CI: 1.23–1.41,P < 0.0001) when PUFA intake is between 18.8 and 29.3 g/day.ConclusionsThe relationship between total PUFA intake and NAFLD is non-linear. Total PUFA was positively related to the risk of NAFLD when PUFA intake is between 18.8 and 29.3 g/day among Chinese Han adults.