Prognostic analysis of hepatocellular carcinoma based on cuproptosis -associated lncRNAs

• DOI: 10.1186/s12876-024-03219-6
• Publication Date: 2024-04-23T13:01:52Z
• Authors: Mingwei Wei; Libai Lu; Zongjiang Luo; Jiasheng Ma; Jianchu Wang
• Keywords: KEGG

Abstract Objectives Cuproptosis represents an innovative type of cell death, distinct from apoptosis, driven by copper dependency, yet the involvement apoptosis-associated long non-coding RNAs (CRLncRNAs) in hepatocellular carcinoma (HCC) remains unclear. This study is dedicated to unveiling role and significance these apoptosis-related lncRNAs within context HCC, focusing on their impact both development disease its prognosis. Methods We conducted analysis gene transcriptomic clinical data for HCC cases sourcing information The Cancer Genome Atlas database. By incorporating cuproptosis-related genes, we established prognostic features associated with lncRNAs. Furthermore, elucidated mechanism prognosis treatment through comprehensive approaches, including Lasso Cox regression analyses, survival analyses samples, as well examinations tumor mutation burden immune function. Results developed a model featuring six lncRNAs: AC026412.3, AC125437.1, AL353572.4, MKLN1-AS, TMCC1-AS1, SLC6A1-AS1. demonstrated exceptional accuracy training validation cohorts patients tumors, showing significantly longer times those categorized low-risk group compared high-risk group. Additionally, our burden, function, Gene Ontology, Kyoto Encyclopedia Genes Genomes pathway enrichment, drug sensitivity, further potential mechanisms which cuproptosis-associated may influence outcome. Conclusions using (lncRNAs) demonstrates promising predictive capabilities immunotherapy outcomes patients. could play crucial patient management optimization immunotherapeutic strategies, offering valuable insights future research.