The prognostic role of albumin-bilirubin grade in the mortality of extrahepatic cholangiocarcinoma patients

• DOI: 10.1186/s12876-025-03979-9
• Publication Date: 2025-05-19T12:02:29Z
• Authors: Fatemeh Dayyan; Farhad Zamani; Hossein Ajdarkosh; Mahmoodreza khoon...; Amirhossein Faraji; Mehdi Nikkhah; Akram Nourian; Fahimeh Safarnezh...; Elham Sobhrakhsha...
• Keywords: Serum Albumin; Surgical oncology

Cholangiocarcinoma (CCA) has a low survival rate of 5-17%, despite advancements in diagnosis and treatment. Liver function impacts disease prognosis, the albumin-bilirubin (ALBI) score is new assessment model for this purpose. While research suggests correlation between ALBI score, liver failure mortality intrahepatic CCA (iCCA), predicting outcomes extrahepatic (eCCA) challenging. Our objective was to assess prognostic role grade overall eCCA patients. Patients with who had visited Firuzgar Hospital from 2015 2019 were consecutively included study. These individuals previously undergone Endoscopic Ultrasound-Guided Fine Needle Aspiration (EUS-FNA) or ERCP brush cytology followed by surgery. Exclusion criteria patients benign bile duct strictures, prior biliary tract surgery, concurrent impacting tests, inadequate data, inconsistent monitoring. Clinical data collected calculate which subsequently divided into three distinct grades (grade 1: ≤-2.60, 2: > -2.60 ≤ - 1.39, 3: >-1.39). Kaplan-Meier analysis Cox regression used analyze survival, 1-, 3- 5-year parameters affecting patient survival. In study, 80 median age 67 (58.25-74) years (67.5% male) included. The average time 13.9 ± 16.4 months, 1-year, 3-year, rates 36.6%, 27.1%, 15.8%, respectively. results showed that grade, Aspartate Aminotransferase (AST), white blood cell (WBC) international normalized ratio (INR) have significant effects on (all P < 0.05). Based regression, risk due 3 (HR = 1.87, 0.0111), AST 82.5 1.90, 0.0091), WBC 7.70 × 109/L 2.46, 0.0004), INR 1.08 1.78, 0.0202) increases significantly. We units/L, can be as predictive factors cholangiocarcinoma