Applicability of Creatinine-based equations for estimating glomerular filtration rate in elderly Chinese patients

• DOI: 10.1186/s12877-021-02428-y
• Publication Date: 2021-09-04T13:02:27Z
• Authors: Fangxiao Xia; Wenke Hao; Jinxiu Liang; Yanhua Wu; Feng Yu; Wenxue Hu; Zhi Zhao; Wei Liu
• Keywords: Interquartile range

Abstract Background The accuracy of the estimated glomerular filter rate (eGFR) in elderly patients is debatable. In 2020, a new creatinine-based equation by European Kidney Function Consortium (EKFC) was applied to all age groups. objective this study assess appropriateness EKFC with Chronic Disease Epidemiology Collaboration (CKD-EPI), Lund-Malmö Revised (LMR), Berlin Initiative Study 1 (BIS1), and full spectrum (FAS) equations based on serum creatinine (SCR) for Chinese patients. Methods A total 612 measured filtration (mGFR) dual plasma sample clearance method Technetium-99 m-diethylenetriamine-pentaacetic acid (Tc-99 m-DTPA) were divided into four subgroups age, sex, mGFR, whether combined diabetes. performance GFR assessed while considering bias, precision, accuracy, root-mean-square error (RMSE). Bland-Altman plots, concordance correlation coefficients (CCCs), evaluate validity eGFR. Results median participants 73 years, 386 (63.1%) male. Referring mGFR (42.1 ml/min/1.73 m 2 ), CKD-EPI, LMR, BIS1, FAS, at 44.4, 41.1, 43.6, 41.8 41.9 , respectively. Overall, smallest bias found BIS1 (− 0.050 vs. range − 3.015 0.795, P <0.05, CKD-EPI equation). Regarding P30, interquartile (IQR), RMSE, category misclassification, generally performed more accurately than other eqs. (73.9%, 12.7, 12.9, 35.3%, respectively). Nevertheless, no achieved optimal mGFR≥60 subgroup. analysis showed mean difference 0.3 ) when compared equations. Conclusions This suggested that most applicable estimating moderate severe renal impairment.