Evaluation of risk factors associated with drug-resistant tuberculosis in Yemen: data from centres with high drug resistance
Medical microbiology
Parasitology
Tropical Medicine
Drug resistant tuberculosis
Extensively drug-resistant tuberculosis
Multi-drug-resistant tuberculosis
DOI:
10.1186/s12879-019-4069-1
Publication Date:
2019-05-24T12:03:22Z
AUTHORS (2)
ABSTRACT
The World Health Organization (WHO) has reported that Yemen a high burden of drug resistance and worrying shortage implemented diagnostic methods treatment regimens. Therefore, in this study, we evaluated the risk factors associated with multidrug-resistant tuberculosis (MDR-TB) explored poor TB management Yemen. Between January 2014 December 2016, enrolled 135 patients MDR-TB from programmes at four major centres for prospective study. After exclusion 20 patients, outcomes were 115 who attended series follow-ups. A total analysed main Most (35.2%) Aden centre. success rate 77.4% was treatment. Of 69.6% resistant to two drugs, 18.3% three 12.2% drugs. During intensive phase treatment, 19 (16.5%) one or more adverse events. multivariate logistic regression analysis revealed baseline body weight ≤40 kg [p = 0.016; adjusted odds ratio (AOR) 25.09], comorbidity (p 0.049; AOR 4.73), lung cavities 0.004; 15.32), positive culture end 0.009; 8.83) unsuccessful drug-resistant patients. achieved after below levels established by WHO End Strategy (90%) United Nations Sustainable Development Goals (80%). Identification is essential because it allows health workers identify high-risk especially absence second-line laboratory method. National Tuberculosis Control Program should formulate new strategies early detection invest management.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (30)
CITATIONS (7)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....