Evaluation of risk factors associated with drug-resistant tuberculosis in Yemen: data from centres with high drug resistance

• DOI: 10.1186/s12879-019-4069-1
• Publication Date: 2019-05-24T12:03:22Z
• Authors: Ammar Ali Saleh J...; Baharudin Ibrahim
• Keywords: Medical microbiology; Parasitology; Tropical Medicine; Drug resistant tuberculosis; Extensively drug-resistant tuberculosis; Multi-drug-resistant tuberculosis

The World Health Organization (WHO) has reported that Yemen a high burden of drug resistance and worrying shortage implemented diagnostic methods treatment regimens. Therefore, in this study, we evaluated the risk factors associated with multidrug-resistant tuberculosis (MDR-TB) explored poor TB management Yemen. Between January 2014 December 2016, enrolled 135 patients MDR-TB from programmes at four major centres for prospective study. After exclusion 20 patients, outcomes were 115 who attended series follow-ups. A total analysed main Most (35.2%) Aden centre. success rate 77.4% was treatment. Of 69.6% resistant to two drugs, 18.3% three 12.2% drugs. During intensive phase treatment, 19 (16.5%) one or more adverse events. multivariate logistic regression analysis revealed baseline body weight ≤40 kg [p = 0.016; adjusted odds ratio (AOR) 25.09], comorbidity (p 0.049; AOR 4.73), lung cavities 0.004; 15.32), positive culture end 0.009; 8.83) unsuccessful drug-resistant patients. achieved after below levels established by WHO End Strategy (90%) United Nations Sustainable Development Goals (80%). Identification is essential because it allows health workers identify high-risk especially absence second-line laboratory method. National Tuberculosis Control Program should formulate new strategies early detection invest management.