Differences in mortality in patients undergoing surgery for infective endocarditis according to age and valvular surgery

• DOI: 10.1186/s12879-020-05422-8
• Publication Date: 2020-09-25T12:03:03Z
• Authors: Lauge Østergaard; Morten Holdgaard ...; Kasper Iversen; Andreas Dalsgaard...; Anders Dahl; Sandra Chamat-Hed...; Niels Eske Bruun; Jawad Haider Butt; Henning Bundgaard; Christian Torp-Pe...; Lars Køber; Emil Fosbøl
• Keywords: Infective Endocarditis

Infective endocarditis (IE) is associated with high mortality. Surgery may improve survival and reduce complications, but the balance between benefit harm difficult be closely related to age type of surgical intervention. We aimed examine how left-sided intervention modified mortality in patients undergoing surgery for IE.By crosslinking nationwide Danish registries we identified first-time IE treatment 2000-2017. Patients were grouped by < 60 years, 60-75 ≥ 75 years. Multivariable adjusted Cox proportional hazard analysis was used factors 90-day mortality.We included 1767 surgery, 735 years (24.1% female), 766 (25.8% 266 ≥75 (36.1% female). The proportions 35.3, 26.9, 9.1% > respectively. Mortality at 90 days 7.5, 13.9, 22.3% (p 0.001) three groups. In analyses, a higher mortality, HR = 1.84 (95% CI: 1.48-2.29) 2.47 1.88-3.24) as compared Factors were: mitral valve combination aortic isolated age, diabetes, prosthetic heart implantation prior admission.In IE, increased significantly 1 5 died above Mitral well multiple interventions augmented further.