Clinical and laboratory findings in COVID-19 adult hospitalized patients from Alborz province / Iran: comparison of rRT-PCR positive and negative

• DOI: 10.1186/s12879-021-05948-5
• Publication Date: 2021-03-11T15:06:05Z
• Authors: Farnaz Karimi; Amir Abbas Vaezi; Mostafa Qorbani; Fatemeh Moghadasi; Saeed Hassani Gel...; Arman Maghoul; Neda Mahmoodi; Zahra Eskandari; Hossein Gholami; Zakiye Mokhames; Mahshid Saleh
• Keywords: Adult; Male; COVID19; rRT-PCR; Clinical findings; Infectious and parasitic diseases; RC109-216; Comorbidity; Iran; 03 medical and health sciences; 0302 clinical medicine; Humans; Aged; Laboratory results; Reverse Transcriptase Polymerase Chain Reaction; Vital Signs; COVID-19; Middle Aged; 3. Good health; Cough; COVID-19 Nucleic Acid Testing; Case-Control Studies; Female; Symptom Assessment; Emergency Service, Hospital; Tomography, X-Ray Computed; Research Article

AbstractBackgroundThe novel coronavirus disease 2019 (COVID-19) was emergency turned into global public health after the first patients were detected in Wuhan, China, in December 2019. The disease rapidly expanded and led to an epidemic throughout China, followed by the rising number of cases worldwide. Given the high prevalence of COVID-19, rapid and accurate diagnostic methods are immediately needed to identify, isolate and treat the patients as soon as possible, decreasing mortality rates and the risk of public contamination by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).MethodsThis case-control study was conducted in two hospitals in Alborz Province in Iran. All recruited cases in this study were symptomatic adults hospitalized as COVID-19 patients with compatible Computed tomographic (CT) scan findings and available rRT-PCR results. The patients were recruited in this study. The patients were categorized into positive and negative rRT-PCR groups and evaluated for symptoms, initial vital signs, comorbidity, clinical and laboratory findings. Finally, the results were assessed by SPSS software.ResultsBetween March 5 to April 5, 2020, 164 symptomatic COVID-19 patients were studied. In total, there were 111 rRT-PCR positive (67.6%) and 53 rRT-PCR negative patients (32.4%). In terms of statistics, the frequency of symptoms revealed no difference, except for cough (P.V:0.008), dizziness (PV: 0.048), and weakness (P.V:0.022). Among initial vital signs, PR (P.V:0.041) and O2 Saturation (PV: 0.014) were statistically different between the two groups. Evaluation of comorbidities revealed no difference except for hyperlipidemia (P.V:0.024). In the comparison of laboratory findings, only WBC count (PV: 0.001), lymphocyte count (PV: 0.001), and Hb (P.V:0.008) were statistically different between the two groups.ConclusionIn case of the negative rRT-PCR result, it is necessary to take a logical approach, and we recommended that the physician decides according to clinical manifestations, laboratory findings, and positive CT results.