Mean platelet volume (MPV): new diagnostic indices for co-morbidity of tuberculosis and diabetes mellitus

• DOI: 10.1186/s12879-021-06152-1
• Publication Date: 2021-05-20T19:09:10Z
• Authors: Feifan Xu; Shengyan Qu; Lin Wang; Yongwei Qin
• Keywords: Mean platelet volume

Abstract Background Tuberculosis (TB) and type 2 diabetes mellitus (DM) are global health diseases with high morbidity mortality. Few studies have focused on platelet indices in TB-DM coinfection patients. The objective of this work was to analyze the TB, DM patients assess predictive value index for risk these diseases. Methods In total, 246 admitted our hospital were distributed into three groups (113 59 74 TB + DM). A total 133 individuals also recruited as healthy controls (HC). Platelet indices, namely, count (PC), mean volume (MPV), plateletcrit (PCT) distribution width (PDW), compared among four groups, relationship inflammatory markers explored by using statistical software. Results Our study discovered that MPV PCT significantly downregulated (9.95 ± 1.25 fL, 0.20 0.05%, P < 0.0001, = 0.0121, separately) (10.92 1.17 0.22 0.04%). Moreover, changes higher 0.0041) than (9.42 1.01 fL). No differences found PLT PDW ( > 0.05). sensitivity specificity differential diagnosis vs 64.9 66.1% 0.0001), respectively, between 60.8 66.4%, respectively 0.003). improved when it combined clinical parameters, such fasting blood glucose Mycobacterium tuberculosis culture result (76.3% 64.9, 72.6% 60.8%, 0.001, respectively). addition, 69.5 59.4%, 0.008). (72.9% 64.9%, 0.004). linked CRP (C-reactive protein) ESR (erythrocyte sedimentation rate) r 0.3203, 0.0054, 0.2504, 0.0307) but not 0.1905, 0.008675, 0.05, Conclusions research shows might be good laboratory distinguish from or individuals, thus providing support earlier diagnosis, prevention, therapy.