From first to second wave: follow-up of the prospective COVID-19 cohort (KoCo19) in Munich (Germany)

• DOI: 10.1186/s12879-021-06589-4
• Publication Date: 2021-09-08T03:30:28Z
• Authors: Katja Radon; Abhishek Bakuli; Peter Pütz; Ronan Le Gleut; Jessica Michelle ...; Laura Olbrich; Elmar Saathoff; Mercè Garí; Yannik Schälte; Turid Frahnow; Roman Wölfel; Michael Pritsch; Camilla Rothe; Michel Pletschette; Raquel Rubio-Acero; Jessica Beyerl; Dafni Metaxa; Felix Forster; Verena Thiel; Noemi Castelletti; Friedrich Rieß; Maximilian N. Die...; Günter Fröschl; Jan Bruger; Simon Winter; Jonathan Frese; Kerstin Puchinger; Isabel Brand; Inge Kroidl; Andreas Wieser; Michael Hoelscher; Jan Hasenauer; Christiane Fuchs; ; Nikolaus Ackermann; Emad Alamoudi; Jared Anderson; Maxilmilian Baumann; Marc Becker; Franziska Bednarzki; Olimbek Bemirayev; Patrick Bitzer; Rebecca Böhnlein; Friedrich Caroli; Josephine Coleman; Lorenzo Contento; Alina Czwienzek; Flora Deák; Jana Diekmannshemke; Gerhard Dobler; Jürgen Durner; Ute Eberle; Judith Eckstein; Tabea Eser; Philine Falk; Manuela Feyereisen; Volker Fingerle; Otto Geisenberger; Christof Geldmacher; Leonard Gilberg; Kristina Gillig; Philipp Girl; Elias Golschan; Elena Maria Gugli...; Pablo Gutierrez; Anslem Haderer; Marlene Hannes; Lena Hartinger; Alejandra Hernandez; Leah Hillari; Christian Hinske; Tim Hofberger; Sacha Horn; Kristina Huber; Christian Janke; Ursula Kappl; Antonia Keßler; Zohaib Khan; Johanna Kresin; Arne Kroidl; Magdalena Lang; Clemens Lang; Silvan Lange; Michael Laxy; Reiner Leidl; Leopold Liedl; Xhovana Lucaj; Fabian Luppa; Alexandra Sophie ...; Petra Mang; Alisa Markgraf; Rebecca Mayrhofer; Hannah Müller; Katharina Müller; Ivana Paunovic; Michael Plank; Claire Pleimelding; Stephan Prückner; Elba Raimúndez; Jakob Reich; Viktoria Ruci; Nicole Schäfer; Benedikt Schluse; Lara Schneider; Mirjam Schunk; Lars Schwettmann; Andreas Sing; Alba Soler; Peter Sothmann; Kathrin Strobl; Jeni Tang; Fabian Theis; Sophie Thiesbrummel; Vincent Vollmayr; Emilia von Lovenberg; Jonathan von Love...; Julia Waibel; Claudia Wallrauch; Julia Wolff; Tobias Würfel; Houda Yaqine; Sabine Zange; Eleftheria Zeggini; Anna Zielke; Thorbjörn Zimmer
• Keywords: Medical microbiology; 2019-20 coronavirus outbreak; Parasitology; Tropical Medicine; Coronavirus Infections

Abstract Background In the 2nd year of COVID-19 pandemic, knowledge about dynamics infection in general population is still limited. Such information essential for health planners, as many those infected show no or only mild symptoms and thus, escape surveillance system. We therefore aimed to describe course pandemic Munich living private households from April 2020 January 2021. Methods The KoCo19 baseline study took place June including 5313 participants (age 14 years above). From November 2021, we could again measure SARS-CoV-2 antibody status 4433 (response 83%). Participants were offered a self-sampling kit take capillary blood sample (dry spot; DBS). Blood was analysed using Elecsys ® Anti-SARS-CoV-2 assay (Roche). Questionnaire on socio-demographics potential risk factors assessed at available all participants. addition, follow-up health-risk taking behaviour number personal contacts outside household (N = 2768) well leisure time activities 1263) collected summer 2020. Results Weighted adjusted (for specificity sensitivity) sero-prevalence 3.6% (95% CI 2.9–4.3%) compared 1.8% 1.3–3.4%) baseline. 91% tested positive also antibody-positive follow-up. While increased early indication geospatial clustering across city found, although cases clustered within households. Taking result into account, men age group 20–34 highest sero-positivity. sensitivity analyses, differences behaviour, partly explained these differences. Conclusion citizens with antibodies below 5% during wave pandemic. Antibodies remained present majority sero-positive Besides sex, potentially confounded by major be identified. Non-pharmaceutical public measures are thus important.