Specific T-cell responses for guiding treatment with convalescent plasma in severe COVID-19 and humoral immunodeficiency: a case report

• DOI: 10.1186/s12879-022-07323-4
• Publication Date: 2022-04-11T12:04:12Z
• Authors: Katarina Nyström; Maria Hjorth; Ramona Fust; Åsa Nilsdotter-Au...; Marie Larsson; Katarina Niward; Sofia Nyström
• Keywords: Humoral immunity; Convalescent plasma; Medical microbiology

Abstract Background The immune response to SARS-CoV-2 virus, the cause of COVID-19, is complex. Antibody mediated responses are important for viral clearance but may also drive hyperinflammation in severe COVID-19. We present a case an individual with genetic inability produce antibodies and receiving no other specific anti-viral treatment than convalescent COVID-19 plasma, illustrating that can occur absence humoral response. In addition, illustrates assessment T cell facilitate clinical decision making patients weak or absent responses. Case presentation A male X-linked agammaglobulinemia on regular immunoglobulin replacement therapy, hospitalized 35 days due Systemic inflammatory parameters were highly elevated. After plasma he became afebrile fatigue diminished. He was discharged day 42 nasopharyngeal PCR eventually negative 49. Evidence cells prior administration therapy suggested crucial clearance. Regular showed robust persistent T-cell after recovery prophylactic unnecessary. Conclusion Assessment SARS-CoV-2T-cell management immunodeficiencies.