HIV-1 pretreatment drug resistance and genetic transmission network in the southwest border region of China

• DOI: 10.1186/s12879-022-07734-3
• Publication Date: 2022-09-19T03:13:30Z
• Authors: Difei Li; Huichao Chen; Huilan Li; Yanling Ma; Lijuan Dong; Jie Dai; Xiaomei Jin; Min Yang; Zhijun Zeng; Pengyan Sun; Zhizhong Song; Min Chen
• Keywords: Medical microbiology; Parasitology; Tropical Medicine

HIV drug resistance increased with the widespread use of antiretroviral drugs, and posed great threat to therapy (ART). Pu'er Prefecture, lying in southwest Yunnan Province, China, borders Myanmar, Laos Vietnam, is also area where AIDS was discovered earlier, however, which there has been no information on resistance.A cross-sectional survey pretreatment (PDR) conducted Prefecture 2021. Partial pol gene sequences were obtained analyze construct genetic transmission network. analyzed using Stanford University HIVdb algorithm.A total 295 obtained, among 11 HIV-1 strain types detected CRF08_BC (62.0%, 183/295) predominant one. Drug mutations (DRMs) 42.4% (125/295) sequences. The prevalence PDR any nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside (NNRTIs) protease (PIs) 10.8% (32/295), 9.5% (28/295), 1.0% (3/295) 0.3% (1/295), respectively. risk occurrence higher individuals CRF01_AE types. molecular network constructed, 56.0% (42/75) links transregional, 54.7% (41/75) associated Lancang County. Among network, 36.8% (35/95) harbored DRMs, (9/95) strains. Furthermore, 8 clusters had shared DRM.The overall this study a moderate level, but NNRTIs very approaching threshold public response initiation. identified DRMs observed. These findings suggested that consecutive surveillance should be region.