Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force

• DOI: 10.1186/s12879-022-07927-w
• Publication Date: 2022-12-12T15:03:19Z
• Authors: Ho Lee; Shotaro Chubachi; Ho Namkoong; Takanori Asakura; Hiromu Tanaka; Shiro Otake; Kensuke Nakagawara; Atsuho Morita; Takahiro Fukushima; Mayuko Watase; Tatsuya Kusumoto; Katsunori Masaki; Hirofumi Kamata; Makoto Ishii; Naoki Hasegawa; Norihiro Harada; Tetsuya Ueda; Soichiro Ueda; Takashi Ishiguro; Ken Arimura; Fukuki Saito; Takashi Yoshiyama; Yasushi Nakano; Yoshikazu Mutoh; Yusuke Suzuki; Koji Murakami; Yukinori Okada; Ryuji Koike; Yuko Kitagawa; Akinori Kimura; Seiya Imoto; Satoru Miyano; Seishi Ogawa; Takanori Kanai; Koichi Fukunaga; ; Ho Lee; Shotaro Chubachi; Ho Namkoong; Takanori Asakura; Hiromu Tanaka; Shiro Otake; Kensuke Nakagawara; Atsuho Morita; Takahiro Fukushima; Mayuko Watase; Tatsuya Kusumoto; Katsunori Masaki; Hirofumi Kamata; Makoto Ishii; Naoki Hasegawa; Norihiro Harada; Tetsuya Ueda; Soichiro Ueda; Takashi Ishiguro; Ken Arimura; Fukuki Saito; Takashi Yoshiyama; Yasushi Nakano; Yoshikazu Mutoh; Yusuke Suzuki; Koji Murakami; Yukinori Okada; Ryuji Koike; Yuko Kitagawa; Akinori Kimura; Seiya Imoto; Satoru Miyano; Seishi Ogawa; Takanori Kanai; Koichi Fukunaga; Kazuhisa Takahashi; Toshio Naito; Makoto Hiki; Yasushi Matsushita; Haruhi Takagi; Ryousuke Aoki; Ai Nakamura; Sonoko Harada; Hitoshi Sasano; Katsunori Masaki; Shinnosuke Ikemura; Satoshi Okamori; Hideki Terai; Takanori Asakura; Junichi Sasaki; Hiroshi Morisaki; Yoshifumi Uwamino; Kosaku Nanki; Yohei Mikami; Sho Uchida; Shunsuke Uno; Rino Ishihara; Yuta Matsubara; Tomoyasu Nishimura; Takunori Ogawa; Toshiro Sato; Masanori Azuma; Ryuichi Saito; Toshikatsu Sado; Yoshimune Miyazaki; Ryuichi Sato; Yuki Haruta; Tadao Nagasaki; Yoshinori Yasui; Yoshinori Hasegawa; Ai Tada; Masayoshi Miyawaki; Masaomi Yamamoto; Eriko Yoshida; Reina Hayashi; Tomoki Nagasaka; Sawako Arai; Yutaro Kaneko; Kana Sasaki; Taisuke Isono; Shun Shibata; Yuma Matsui; Chiaki Hosoda; Kenji Takano; Takashi Nishida; Yoichi Kobayashi; Yotaro Takaku; Noboru Takayanagi; Etsuko Tagaya; Masatoshi Kawana; Yasushi Nakamori; Kazuhisa Yoshiya; Fukuki Saito; Tomoyuki Yoshihara; Daiki Wada; Hiromu Iwamura; Syuji Kanayama; Shuhei Maruyama; Takanori Hasegawa; Kunihiko Takahashi; Tatsuhiko Anzai; Satoshi Ito; Akifumi Endo; Yuji Uchimura; Yasunari Miyazaki; Takayuki Honda; Tomoya Tateishi; Shuji Tohda; Naoya Ichimura; Kazunari Sonobe; Chihiro Tani Sassa; Jun Nakajima; Masumi Ai; Ken Hiroyuki Ohta...; Hideo Ogata; Yoshiaki Tanaka; Kenichi Arakawa; Masafumi Shimoda; Takeshi Osawa; Yukiko Nakajima; Ryusuke Anan; Ryosuke Arai; Yuko Kurihara; Yuko Harada; Kazumi Nishio; Tomonori Sato; Reoto Takei; Satoshi Hagimoto; Yoichiro Noguchi; Yasuhiko Yamano; Hajime Sasano; Sho Ota; Sohei Nakayama; Keita Masuzawa; Tomomi Takano; Kazuhiko Katayama; Koji Murakami; Mitsuhiro Yamada; Hisatoshi Sugiura; Hirohito Sano; Shuichiro Matsumoto; Nozomu Kimura; Yoshinao Ono; Hiroaki Baba; Rie Baba; Daisuke Arai; Takayuki Ogura; Hidenori Takahashi; Shigehiro Hagiwara; Genta Nagao; Shunichiro Konishi; Ichiro Nakachi; Hiroki Tateno; Isano Hase; Shuichi Yoshida; Shoji Suzuki; Miki Kawada; Hirohisa Horinouchi; Fumitake Saito; Keiko Mitamura; Masao Hagihara; Junichi Ochi; Tomoyuki Uchida; Ryuya Edahiro; Yuya Shirai; Kyuto Sonehara; Tatsuhiko Naito; Kenichi Yamamoto; Shinichi Namba; Ken Suzuki; Takayuki Shiroyama; Yuichi Maeda; Takuro Nii; Yoshimi Noda; Takayuki Niitsu; Yuichi Adachi; Takatoshi Enomoto; Saori Amiya; Reina Hara; Noa Sasa; Shuhei Yamada; Toshihiro Kishikawa; Kazunori Tomono; Kazuto Kato Shuhe...; Yuya Ueno; Motoyuki Suzuki; Norihiko Takemoto; Hirotaka Eguchi; Takahito Fukusumi; Takao Imai; Munehisa Fukushima; Masatoshi Takagaki; Haruhiko Kishima; Hidenori Inohara; Haruhiko Hirata; Yoshito Takeda; Atsushi Kumanogoh; Naoki Miyazawa; Yasuhiro Kimura; Reiko Sado; Hideyasu Sugimoto; Akane Kamiya; Naota Kuwahara; Akiko Fujiwara; Tomohiro Matsunaga; Yoko Sato; Takenori Okada; Takashi Inoue; Toshiyuki Hirano; Keigo Kobayashi; Hatsuyo Takaoka; Koichi Nishi; Masaru Nishitsuji; Mayuko Tani; Junya Suzuki; Hiroki Nakatsumi; Hidefumi Koh; Tadashi Manabe; Yohei Funatsu; Fumimaro Ito; Takahiro Fukui; Keisuke Shinozuka; Sumiko Kohashi; Masatoshi Miyazaki; Tomohisa Shoko; Mitsuaki Kojima; Tomohiro Adachi; Motonao Ishikawa; Kenichiro Takahashi; Kazuyoshi Watanabe; Yoshihiro Hirai; Hidetoshi Kawashima; Atsuya Narita; Kazuki Niwa; Yoshiyuki Sekikawa; Hisako Sageshima; Yoshihiko Nakamura; Kota Hoshino; Junichi Maruyama; Hiroyasu Ishikura; Tohru Takata; Takashi Ogura; Hideya Kitamura; Eri Hagiwara; Kota Murohashi; Hiroko Okabayashi; Takao Mochimaru; Shigenari Nukaga; Ryosuke Satomi; Yoshitaka Oyamada; Nobuaki Mori; Tomoya Baba; Yasutaka Fukui; Mitsuru Odate; Shuko Mashimo; Yasushi Makino; Kazuma Yagi; Mizuha Hashiguchi; Junko Kagyo; Tetsuya Shiomi; Kodai Kawamura; Kazuya Ichikado; Kenta Nishiyama; Hiroyuki Muranaka; Kazunori Nakamura; Satoshi Fuke; Hiroshi Saito; Tomoya Tsuchida; Shigeki Fujitani; Mumon Takita; Daiki Morikawa; Toru Yoshida; Takehiro Izumo; Minoru Inomata; Naoyuki Kuse; Nobuyasu Awano; Mari Tone; Akihiro Ito; Toshio Odani; Masaru Amishima; Takeshi Hattori; Yasuo Shichinohe; Takashi Kagaya; Toshiyuki Kita; Kazuhide Ohta; Satoru Sakagami; Kiyoshi Koshida; Morio Nakamura; Koutaro Yokote; Taka-Aki Nakada; Ryuzo Abe; Taku Oshima; Tadanaga Shimada; Kentaro Hayashi; Tetsuo Shimizu; Yutaka Kozu; Hisato Hiranuma; Yasuhiro Gon; Namiki Izumi; Kaoru Nagata; Ken Ueda; Reiko Taki; Satoko Hanada; Naozumi Hashimoto; Keiko Wakahara; Koji Sakamoto; Norihito Omote; Akira Ando; Yu Kusaka; Takehiko Ohba; Susumu Isogai; Aki Ogawa; Takuya Inoue; Nobuhiro Kodama; Yasunari Kaneyama; Shunsuke Maeda; Takashige Kuraki; Takemasa Matsumoto; Masahiro Harada; Takeshi Takahashi; Hiroshi Ono; Toshihiro Sakurai; Takayuki Shibusawa; Yusuke Kawamura; Akiyoshi Nakayama; Hirotaka Matsuo; Yoshifumi Kimizuka; Akihiko Kawana; Tomoya Sano; Chie Watanabe; Ryohei Suematsu; Makoto Masuda; Aya Wakabayashi; Hiroki Watanabe; Suguru Ueda; Masanori Nishikawa; Ayumi Kazuto Yosh...; Saeko Takahashi; Kota Ishioka; Yusuke Chihara; Mayumi Takeuchi; Keisuke Onoi; Jun Shinozuka; Atsushi Sueyoshi; Yoji Nagasaki; Masaki Okamoto; Yoshihisa Tokunaga; Sayoko Ishihara; Masatoshi Shimo; Masafumi Watanabe; Sumito Inoue; Akira Igarashi; Masamichi Sato; Nobuyuki Hizawa; Yoshiaki Inoue; Shigeru Chiba; Kunihiro Yamagata; Hirayasu Kai; Yuji Hiramatsu; Satoru Fukuyama; Keiko Kan-o; Koichiro Matsumoto; Yoshihiro Eriguchi; Akiko Yonekawa; Kensuke Kanaoka; Shoichi Ihara; Kiyoshi Komuta; Koichiro Asano; Tsuyoshi Oguma; Yoko Ito; Satoru Hashimoto; Masaki Yamasaki; Yu Kasamatsu; Yuko Komase; Naoya Hida; Takahiro Tsuburai; Baku Oyama; Yuichiro Kitagawa; Tetsuya Fukuta; Takahito Miyake; Shozo Yoshida; Shinji Ogura; Minoru Takada; Hidenori Kanda; Shinji Abe; Yuta Kono; Yuki Togashi; Hiroyuki Takoi; Ryota Kikuchi; Shinichi Ogawa; Tomouki Ogata; Shoichiro Ishihara; Arihiko Kanehiro; Shinji Ozaki; Yasuko Fuchimoto; Sae Wada; Nobukazu Fujimoto; Kei Nishiyama; Mariko Terashima; Satoru Beppu; Kosuke Yoshida; Osamu Narumoto; Hideaki Nagai; Nobuharu Ooshima; Mitsuru Motegi; Akira Umeda; Kazuya Miyagawa; Hisato Shimada; Mayu Endo; Yoshiyuki Ohira; Hironori Sagara; Akihiko Tanaka; Shin Ohta; Tomoyuki Kimura; Yoko Shibata; Yoshinori Tanino; Takefumi Nikaido; Hiroyuki Minemura; Yuki Sato; Yuichiro Yamada; Takuya Hashino; Masato Shinoki; Hajime Iwagoe; Hiroshi Takahashi; Kazuhiko Fujii; Hiroto Kishi; Tomoo Ishii; Masayuki Kanai; Tomonori Imamura; Tatsuya Yamashita; Masakiyo Yatomi; Toshitaka Maeno; Shinichi Hayashi; Mai Takahashi; Mizuki Kuramochi; Isamu Kamimaki; Yoshiteru Tominaga; Mitsuyoshi Utsugi; Akihiro Ono; Toru Tanaka; Takeru Kashiwada; Kazue Fujita; Yoshinobu Saito; Masahiro Seike; Masahiro Kanai; Ryunosuke Saiki; Yasuhito Nannya; Takayoshi Hyugaji; Eigo Shimizu; Kotoe Katayama; Satoru Miyawaki; Meiko Takahashi; Fumihiko Matsuda; Yosuke Omae; Katsushi Tokunaga; Takafumi Ueno
• Keywords: Medical microbiology; Tocilizumab

We aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization Japan, by COVID-19 waves, from conventional strains Delta variant.We used secondary data a database and performed retrospective cohort study that included 3261 aged ≥ 18 years enrolled 78 hospitals participated Japan Task Force between February 2020 September 2021.Patients hospitalized during second (mean age, 53.2 [standard deviation {SD}, ± 18.9]) fifth 50.7 [SD 13.9]) waves had lower mean age than those other waves. Patients first wave longer hospital stay (mean, 30.3 days 21.5], p < 0.0001), post-hospitalization complications, such as bacterial infections (21.3%, were also noticeable. In addition, there was an increase use drugs remdesivir/baricitinib/tocilizumab/steroids latter wave, exhibited greater number presenting symptoms, higher percentage required oxygen therapy at time admission. However, invasive mechanical ventilation highest mortality rate third wave.We identified clinical each up Japan. The associated severity on admission, rate, ventilation.