Beyond prediction: unveiling the prognostic power of μ-opioid and cannabinoid receptors, alongside immune mediators, in assessing the severity of SARS-CoV-2 infection

• DOI: 10.1186/s12879-024-09280-6
• Publication Date: 2024-04-12T15:01:59Z
• Authors: Masoumeh Tavakoli...; Aida Abbasi; Fatemeh Nejat Pis...; Saeed Baranipour; Alireza Jahangiri...; Seyed Bashir Mirt...; Zahra Noorani Mej...; Mohammad Amin Vaezi; Jila Yavarian; Bahare Abdollahi; Talat Mokhtari-Azad; Vahid Salimi
• Keywords: Osteopontin; Medical microbiology

Abstract Background This study aims to explore the potential of utilizing expression levels cannabinoid receptor 2 (CB2), μ-opioid (MOR), MCP-1, IL-17, IFN-γ, and osteopontin as predictors for severity SARS-CoV-2 infection. The overarching goal is delineate pathogenic mechanisms associated with SARS-CoV-2. Methods Using quantitative Real-time PCR, we analyzed gene CB2 MOR in nasopharynx specimens obtained from patients diagnosed infection, 46 individuals classified having severe symptoms non-severe. Additionally, measured circulating using an ELISA assay. We examined predictive capabilities these variables explored their correlations across all patient groups. Results Our results demonstrated a significant increase epithelium was also elevated both male female symptoms. Furthermore, observed concurrent rises patients, which were linked disease severity. CB2, MOR, showed strong abilities distinguishing between varying degrees Moreover, identified correlation osteopontin, IFN-γ. Conclusions These underline interconnected nature molecular mediators sequential manner, suggesting that overexpression may play role development infections. Graphical