The difference between patients with nephrotic syndrome and nephrotic-range proteinuria in IgA nephropathy: a propensity score matched cohort study

• DOI: 10.1186/s12882-022-02799-3
• Publication Date: 2022-04-29T11:03:52Z
• Authors: Hongfen Li; Fanghao Wang; Junya Jia; Tiekun Yan; Youxia Liu; Shan Lin
• Keywords: Nephrology; Minimal change disease; Nephrosis

Abstract Objective To date, nephrotic syndrome (NS) has not been well characterized in patients with IgA nephropathy (IgAN). Whether decline serum albumin is an ominous sign IgAN massive proteinuria remains unknown. In this study, we evaluated clinical and pathological features of NS compared the differences for these long-term outcomes between nephrotic-range proteinuria. Methods A retrospective study was conducted, enrolling 1013 biopsy-proven IgAN. The primary endpoint composite a doubling base-line creatinine, 50% reduction eGFR, ESKD (eGFR < 15 ml/min per 1.73 m 2 ) or death. Results total 59 were presented (5.8%). showed lower levels hemoglobin, higher uric acid urinary protein than without NS. As parameters, more prevalence E1 lesions, T1/2 C1/2 lesions. Furthermore, used propensity score matching method to select 57 normal (NR group) who comparable Patients had IgG TC, LDL, FIB D-dimer as severe lesions those NR group. S1 lesion group that There no significant difference outcome two groups. addition, found level presence hypoalbuminemia risk factor affecting Conclusions 5.8% adult our study. low albumin, high acid, acute prognosis inferior range albumin.