Longitudinal extensive transverse myelitis following ChAdOx1 nCOV-19 vaccine: a case report

• DOI: 10.1186/s12883-021-02427-x
• Publication Date: 2021-10-12T22:08:29Z
• Authors: Wee Yong Tan; Abdul Hanif Khan ...; Mohd Naim Mohd Ya...; Anna Misyail Abdu...; Wei Chao Loh; Janudin Baharin; Azliza Ibrahim; Mohd Redzuan Ismail; Liyana Najwa Inch...; Wan Aliaa Wan Sul...; Hamidon Basri; Fan Kee Hoo
• Keywords: Acute Transverse Myelitis; Acute disseminated encephalomyelitis

Transverse myelitis (TM) is a relatively uncommon condition, and vaccine-associated even rarer. Concern regarding neurological complications following vaccination escalated the report of TM during safety efficacy trials COVID-19 vaccine.We first case Longitudinal Extensive Myelitis (LETM) in Malaysia administration chimpanzee adenovirus-vectored (ChAdOx1 nCoV-19) vaccine. A 25-year-old female presented with bilateral lower limb weakness inability to walk sensory level up T8 absent visual symptoms. Urgent gadolinium-enhanced magnetic resonance imaging (MRI) spine showed long segment over thoracic region. Cerebrospinal fluid autoantibodies for anti-aquaporin-4 anti-myelin-oligodendrocyte were negative. diagnosis LETM was made, patient started on high dose intravenous methylprednisolone. The eventually made recovery treatment.LETM rare but serious adverse reaction vaccination. Previously reported cases an onset symptoms between 10 14 days post-vaccination, suggesting delayed immunogenic reaction. However, incidence much more common, far greater than risk associated