Triglyceride glucose index influences platelet reactivity in acute ischemic stroke patients

• DOI: 10.1186/s12883-021-02443-x
• Publication Date: 2021-10-26T12:02:54Z
• Authors: Yinping Guo; Jing Zhao; Yi Zhang; Lingshan Wu; Zhiyuan Yu; Dan He; Hao Huang; Wensheng Qu; Xiang Luo
• Keywords: Neurochemistry; Stroke; Ischaemic stroke

Insulin resistance was reported to increase the risk of ischemic stroke, which can be assessed by triglyceride glucose (TyG) index. However, it remains unclear whether TyG index influences platelet reactivity during treatment patients.Ischemic stroke patients receiving dual antiplatelet therapy (DAPT) within 48 h onset were consecutively included. The calculated as ln (fasting [mg/dL] × fasting [mg/dL]/2). top quartile defined insulin resistance. thromboelastography. inhibition rate induced arachidonic acid (AA) or adenosine diphosphate (ADP) used confirm high residual on-treatment (HRPR) aspirin clopidogrel, respectively. association between and Kruskal-Wallis test. independent factors HRPR determined multivariate logistic regression analysis.A total 1002 included divided into 4 groups quartiles (< 2.02; 2.02-2.27; 2.27-2.52; ≥2.52). findings demonstrated that maximum intensity clot increased, but AA-induced decreased, depending on quartiles. No significant difference found in ADP-induced among groups. prevalence increased quartile. Unlike non-insulin group, group independently associated with (OR = 1.689, 95% CI 1.14 2.51, P 0.009).In acute taking DAPT, elevation is enhanced higher HRPR. could an factor for