Association of blood pressure parameters on early neurological deterioration in patients with mild stroke and large vessel occlusion following medical management

• DOI: 10.1186/s12883-025-04066-y
• Publication Date: 2025-02-11T14:17:42Z
• Authors: Yue Shi; Jianwen Bu; Jian-yu Liu; Shankai Liu
• Keywords: Neurochemistry; Stroke; Association (psychology)

To explore the association between blood pressure (BP) metrics and early neurological deterioration of ischemic origin (ENDi) in patients with mild stroke large vessel occlusion (LVO) undergoing best medical management (BMM). Data were collected from consecutive LVO treated BMM January 2019 to December 2023. Admission systolic (SBP), diastolic (DBP), mean arterial (MAP) 24-h SBP variability calculated. ENDi was defined as an National Institutes Health Stroke Scale (NIHSS) score increase ≥ 4 points within 24 h, excluding intracranial hemorrhage. Among 347 patients, occurred 42 (12.1%). The group exhibited higher admission (158 vs. 131 mmHg, P < 0.001), (32 14 Tmax > 6 s volumes (63 40 ml, a greater proportion had vertebrobasilar (42.9% 12.1%, 0.001). Multivariable analysis indicated that highest quartile for (adjusted odds ratio [aOR] = 2.47, 95% confidence interval [CI] 1.47–4.29), (aOR 2.57, CI 1.34–5.18), 2.09, 1.28–5.89) independently associated ENDi. Significant also existed 3.19, 1.76–6.74). Significantly elevated occurrence receiving BMM.