Cardiac dysfunction and remodeling regulated by anti-angiogenic environment in patients with preeclampsia: the ANGIOCOR prospective cohort study protocol

• DOI: 10.1186/s12884-021-04263-w
• Publication Date: 2021-12-08T12:04:12Z
• Authors: Johana Ullmo; Monica Cruz-Lemini; Olga Sánchez-García; Lidia Bos-Real; Patricia Fernande...; Francesca Calero; Carla Domínguez-G...; Carmen Garrido-Gi...; Cristina Trilla; Francesc Carreras...; Alessandro Sionis; Josefina Mora; Álvaro García-Osuna; Jordi Ordoñez-Llanos; Elisa Llurba
• Keywords: Adult; Heart Diseases; Pregnancy Trimester, Third; Neovascularization, Physiologic; sFlt-1; Cohort Studies; Study Protocol; 03 medical and health sciences; 0302 clinical medicine; Pre-Eclampsia; Pregnancy; Humans; Prospective Studies; Cardiac remodeling; Placenta Growth Factor; Angiogenic factors; Vascular Endothelial Growth Factor Receptor-1; Gynecology and obstetrics; Preeclampsia; Cardiovascular risk; 3. Good health; Pregnancy Complications; Cardiac biomarkers; Pregnancy Trimester, First; PlGF; Echocardiography; Heart Disease Risk Factors; Spain; Case-Control Studies; RG1-991; Cardiac dysfunction; Female; Biomarkers

Cardiovascular diseases (CVD) are cause of increased morbidity and mortality in spite advances for diagnosis treatment. Changes during pregnancy affect importantly the maternal CV system. Pregnant women that develop preeclampsia (PE) have higher risk (up to 4 times) clinical CVD short- long-term. Predominance an anti-angiogenic environment is known as main PE, but its relationship with complications still under research. We hypothesize angiogenic factors associated cardiac dysfunction/remodeling these may be detected by new biomarkers echocardiography.