Serum gamma-glutamyltransferase and the overall survival of metastatic pancreatic cancer

• DOI: 10.1186/s12885-019-6250-8
• Publication Date: 2019-10-30T20:44:43Z
• Authors: Yuanyuan Xiao; Haijun Yang; Jian Lu; Dehui Li; Chuanzhi Xu; Harvey A. Risch
• Keywords: Male; 0301 basic medicine; China; Survival; Hospitals, University; 03 medical and health sciences; 0302 clinical medicine; Risk Factors; Biomarkers, Tumor; Humans; RC254-282; Aged; Proportional Hazards Models; Retrospective Studies; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Pancreatic cancer; gamma-Glutamyltransferase; Middle Aged; Prognosis; 3. Good health; Pancreatic Neoplasms; Survival Rate; Female; Biomarkers; Research Article; Carcinoma, Pancreatic Ductal

Abstract

Background Accumulating evidence suggests that Gamma-glutamyltransferase (GGT) may be involved in cancer occurrence and progression. However, the prognostic role of serum GGT in pancreatic cancer (PC) survival lacks adequate evaluation. In this study, we aimed to analyze the association between serum GGT measured at diagnosis and overall survival (OS) in patients with metastatic PC.

Methods We identified 320 patients with histopathologically confirmed metastatic pancreatic ductal adenocarcinoma (PDAC) diagnosed during 2015 and 2016 at a specialized cancer hospital in southwestern China. Univariate and multivariate Cox proportional-hazards models were used to determine associations between serum GGT and OS in metastatic PDAC.

Results Controlled for possible confounding factors, serum GGT was significantly associated with OS: serum GGT > 48 U/L yielded a hazard ratio of 1.53 (95% CI: 1.19–1.97) for mortality risk. A significant dose-response association between serum GGT and OS was also observed. Subgroup analysis showed a possible interaction between GGT and blood glucose level.

Conclusion Serum GGT could be a potential indicator of survival in metastatic PDAC patients. Underlying mechanisms for this association should be investigated.