Cancer incidence and mortality trends in France over 1990–2018 for solid tumors: the sex gap is narrowing

• DOI: 10.1186/s12885-021-08261-1
• Publication Date: 2021-06-24T04:03:18Z
• Authors: G. Defossez; Z. Uhry; P. Delafosse; E. Dantony; T. d’Almeida; S. Plouvier; N. Bossard; A. M. Bouvier; F. Molinié; A. S. Woronoff; M. Colonna; P. Grosclaude; L. Remontet; A. Monnereau; ; Brice Amadeo; Isabelle Baldi; Simona Bara; Anne-Marie Bouvier; Véronique Bouvier; Marc Colonna; Gaëlle Coureau; Anne Cowppli-Bony; Sandrine Dabakuyo...; Tania d’Almeida; Laetitia Daubisse...; Gautier Defossez; Patricia Delafosse; Emmanuel Desandes; Pascale Grosclaude; Anne-Valérie Guizard; Brigitte Lacour; Bénédicte Lapôtre...; Karima Hammas; Florence Molinié; Jean-Baptiste Nou...; Sandrine Plouvier; Camille Pouchieu; Michel Robaszkiewicz; Claire Schvartz; Brigitte Trétarre; Michel Velten; Anne-Sophie Woronoff
• Keywords: Male; [SDV]Life Sciences [q-bio]; Research; Incidence; 610; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Gender Identity; History, 20th Century; History, 21st Century; 3. Good health; [SDV] Life Sciences [q-bio]; 03 medical and health sciences; 0302 clinical medicine; Neoplasms; Humans; Sex; Female; Registries; Mortality; Trends; RC254-282; Cancer

Abstract Objective To analyze trends in cancer incidence and mortality (France, 1990–2018), with a focus on men-women disparities. Methods Incidence data stemmed from registries (FRANCIM) national statistics (CépiDc). rates were modelled using bidimensional penalized splines of age year (at diagnosis at death, respectively). Trends age-standardized summarized by the average annual percent changes (AAPC) for all-cancers combined, 19 solid tumors, 8 subsites. Sex gaps indicated male-to-female rate ratios (relative difference) differences (absolute 1990 2018, mortality, respectively. Results For all-cancers, sex gap narrowed over 1990–2018 (1.6 to 1.2) (2.3 1.7). The largest decreases ratio cancers lung (9.5 2.2), lip - oral cavity pharynx (10.9 3.1), esophagus (12.6 4.5) larynx (17.1 7.1). Mixed emerged oesophageal cancers, probably explained differing risk factors two main histological subtypes. due increasing men women skin melanoma (0.7 1, initially higher women), liver (7.4 4.4) pancreas (2.0 1.4). colon-rectum (1.7 1.4), urinary bladder (6.9 6.1) stomach (2.7 2.4) driven decreasing among men. Other showed similar both sexes leading stable gaps: thyroid gland (0.3 0.3), kidney (2.2 central nervous system (1.4 1.5). Conclusion In France while still had risks developing or dying most was narrowing. Efforts should avoiding (e.g., smoking) etiological studies understand currently unexplained trends.