Efficacy of 1% carboxymethylcellulose sodium for treating dry eye after phacoemulsification: results from a multicenter, open-label, randomized, controlled study

• DOI: 10.1186/s12886-015-0005-3
• Publication Date: 2015-03-19T17:22:57Z
• Authors: Ke Yao; Yongzhen Bao; Jian Ye; Yi Lu; Hongsheng Bi; Xin Tang; Yune Zhao; Jinsong Zhang; Jinling Yang
• Keywords: Tolerability; Sodium hyaluronate; Open label; Artificial tears

For patients who experience dry eye after phacoemulsification, vision and quality of life can significantly deteriorate. In this study, the efficacy safety carboxymethylcellulose sodium (CMC) 1% ophthalmic solution combined with conventional therapy in treating signs symptoms phacoemulsification were evaluated.In prospective, multicenter, open-label, controlled 180 age-related cataract randomized to treatment plus CMC (n = 90) or only (control group, n intraocular lens implantation. Tear breakup time (TBUT), Schirmer test anesthesia, fluorescein lissamine green staining performed. The Ocular Surface Disease Index (OSDI) questionnaire a patient subjective symptom evaluation administered preoperatively (baseline) postoperatively at 7 30 days.TBUT was longer group compared control day (8.5 ± 5.5 versus 6.6 3.8 s; P 0.0475) (9.0 5.9 6.7 4.8 0.0258) surgery. Compared baseline, TBUT increased (P < 0.001 both 30) presurgical diagnosis eye, but decreased 0.02 no prior eye. Fluorescein staining, OSDI scores all improved from significant differences between two groups. No tolerability observed receiving therapy, those only.Treatment provide improvement tear film stability for cataract.ClinicalTrials.gov identifier NCT02028754 (Date registration: Jan. 6, 2014).