The NeBoP score - a clinical prediction test for evaluation of children with Lyme Neuroborreliosis in Europe

• DOI: 10.1186/s12887-015-0537-y
• Publication Date: 2015-12-17T03:59:59Z
• Authors: Barbro H. Skogman; Johanna Sjöwall; Per-Eric Lindgren
• Keywords: Lyme Neuroborreliosis; Neuroborreliosis

The diagnosis of Lyme neuroborreliosis (LNB) in Europe is based on clinical symptoms and laboratory data, such as pleocytosis anti-Borrelia antibodies serum CSF according to guidelines. However, the decision start antibiotic treatment admission cannot be Borrelia serology since results are not available at time lumbar puncture. Therefore, an early prediction test would useful practice. aim study was develop evaluate a for children with LNB relevant European setting. Clinical data were collected retrospectively from cohort being evaluated Southeast Sweden. A test, NeBoP score, designed differentiate between high low risk having LNB. score then prospectively validated Central Sweden (n = 190) controls other specific diagnoses 49). sensitivity 90 % (CI 95 %; 82–99 %) specificity 85–96 %). Thus, diagnostic accuracy (i.e. how correctly discriminates patients controls) area under curve ROC analysis 0.95. positive predictive value (PPV) 0.83 0.75–0.93) negative (NPV) 0.95 0.90–0.99). overall performance (90 suggested decision-making about endemic areas.