Global, regional, and national time trends in cancer mortality attributable to high fasting plasma glucose: an age-period cohort analysis

• DOI: 10.1186/s12889-023-16076-x
• Publication Date: 2023-07-15T05:01:47Z
• Authors: Jing Xie; Zeye Liu; Liqun Ren; Liyun He; Shan Lu; Xiangzhi Meng; Xin Zhang; Zhanhao Su; Shenqi Jing; Tao Shan; Junjie Wang; Ruibing Xia; Wei Feng; Yakun Li; Naifeng Liu; Yun Liu
• Keywords: Biostatistics; Cohort effect

Abstract Background High fasting plasma glucose (HFPG) is the fastest-growing risk factor for cancer deaths worldwide. We reported mortality attributable to HFPG at global, regional, and national levels over past three decades associations with age, period, birth cohort. Methods Data this study were retrieved from Global Burden of Disease Study 2019, we used age-period-cohort modelling estimate cohort period effects, as well net drift (overall annual percentage change) local (annual change in each age group). Results Over 30 years, global age-standardized rate (ASMR) has increased by 27.8%. The ASMR 2019 was highest male population high sociodemographic index (SDI) areas (8.70; 95% CI, 2.23–18.04). female low SDI (2.33; 2.12–2.55). Unfavourable effects found across all quintiles. Cancer subtypes such "trachea, bronchus, lung cancers", "colon rectal "breast cancer" "pancreatic exhibited similar trends. Conclusions surged during decades. on observed quintiles, expected continue increase rapidly future, particularly lower locations. This a grim public health issue that requires immediate attention.