Is daily physical activity affected by dynamic hyperinflation in adults with cystic fibrosis?

• DOI: 10.1186/s12890-018-0623-7
• Publication Date: 2018-04-19T07:24:54Z
• Authors: Daniela Savi; Marcello Di Paolo; Nicholas J. Simmonds; Chiara Pascucci; Serena Quattrucci; Paolo Palange
• Keywords: Adult; Male; SYMPTOMS; cystic fibrosis; daily physical activity; dynamic hyperinflation; exercise intolerance; pulmonary and respiratory medicine; Exercise intolerance; Cystic Fibrosis; Respiratory System; 610; CHILDREN; OBSTRUCTIVE PULMONARY-DISEASE; 1102 Cardiovascular Medicine And Haematology; Cystic fibrosis; Diseases of the respiratory system; 03 medical and health sciences; Oxygen Consumption; 0302 clinical medicine; Forced Expiratory Volume; Humans; LUNG-VOLUMES; Exercise; Lung; Dynamic hyperinflation; EXERCISE INTOLERANCE; Science & Technology; Exercise Tolerance; RC705-779; STANDARDIZATION; 3. Good health; Italy; Daily physical activity; MECHANICS; Multivariate Analysis; Exercise Test; Linear Models; Female; Life Sciences & Biomedicine; Inspiratory Capacity; Research Article

The aim of this study was to investigate the relationship between dynamic hyperinflation and daily physical activity (DPA) in adults with cystic fibrosis (CF).Thirty-four clinically stable CF were studied. All patients undertook incremental cardiopulmonary exercise testing (CPET). CPET-related measurements included: oxygen uptake (V'O2), carbon dioxide production (V'CO2), ventilatory profile, work rate (W), inspiratory capacity (IC), end-expiratory lung volume (EELV). PA was assessed using the accelerometer SenseWear Pro3 Armband.Exercise tolerance was reduced in most of patients and the mean V'O2,peak value was 75.2% of predicted (28.5 ± 4.8 ml/min/kg). Seventy % of patients responded to CPET with dynamic hyperinflation. Higher incidence of dynamic hyperinflation was found in CF males compared to CF females (p = 0.026). Patients who developed dynamic hyperinflation during CPET had higher vigorous PA (p = 0.01) and more total energy expenditure (p = 0.006) than patients who did not. EELVΔ was related to activities requiring vigorous intensity and total energy expenditure (R = 0.46, p = 0.001; R = 0.57, p < 0.001).In adults with CF and mild to moderate lung impairment, DPA might not be limited by dynamic hyperinflation.