Systemic inflammation and sympathetic activation in gestational diabetes mellitus with obstructive sleep apnea

• DOI: 10.1186/s12890-022-01888-1
• Publication Date: 2022-03-18T18:02:53Z
• Authors: Oleksandr Seredny...; Alberto Alonso-Fe...; Caterina Ribot; Andrea Herranz; Ainhoa Álvarez; Andrés Sánchez; Paula Rodríguez; Ana V. Gil; Carla Pía; José P. Cubero; María Barceló; María Cerdà; Mercedes Codina; Mónica D. Peña; Antònia Barceló; Amanda Iglesias; Daniel Morell-Garcia; José A. Peña; María P. Giménez; María C. Piñas; Francisco García-Río
• Keywords: Apnea–hypopnea index

Abstract Background Although some evidence suggests an association between obstructive sleep apnea (OSA) and gestational diabetes mellitus (GDM), its consequences still remain largely unknown. We sought to determine whether OSA is associated with higher inflammation sympathetic levels in GDM, relate them insulin resistance perinatal outcomes. Methods was identified by polysomnography defined as apnea–hypopnea index of ≥ 5 h −1 . Plasma cytokines (TNF-α, IL-1β, IL-6, IL-8, IL-10), metanephrine, normetanephrine were determined immunoassays. Results included 17 patients GDM 34 without OSA. Women had concentrations [81 IQR (59–134) vs. 68 (51–81) pg/mL]. No differences the inflammatory profile found, while IL-1β mean nocturnal oxyhemoglobin saturation ≤ 94%. found positive correlations increased activation apneas, time REM showed inverse relationship metanephrine. Furthermore, IL-10 inversely related stages 1–2, arousal index, it positively slow-wave sleep. Significant also resistance. There no significant neonatal characteristics; however, we relationships birth weight (BW), percentile BW. Conclusions activity, concentration lower oxygenation, all which events, REM. Moreover, resistance, correlated