Obstructive sleep apnea and nocturnal hypoxemia in adult patients with cystic fibrosis

• DOI: 10.1186/s12890-022-02243-0
• Publication Date: 2022-11-28T04:30:16Z
• Authors: Matthias Welsner; Sarah Dietz-Terjung; Florian Stehling; Tim Schulte; Ute Niehammer; Fatma-Ezzahra Gah...; Christian Taube; Svenja Strassburg; Christoph Schoebel; Gerhard Weinreich; Sivagurunathan Su...
• Keywords: Epworth Sleepiness Scale; Apnea–hypopnea index; Oxygen Saturation

Obstructive sleep apnea (OSA), nocturnal hypoxemia and excessive daytime sleepiness (EDS) are common comorbidities in people with cystic fibrosis (pwCF). Most of the data showing this originates from children adolescents. The aim study was to collect on parameters, EDS pulmonary function a large cohort adult pwCF.Full overnight polysomnography (PSG) performed. determined using Epworth Sleepiness Scale (ESS). Demographic clinical (body mass index [BMI], function, capillary blood gases) were collected.A total 52 pwCF included (mean age 30.7 ± 8.0 years, mean percent predicted forced expiratory volume 1 s [ppFEV1] 52.1 14.8). Overall AHI normal range (4.5 4.0/h); 21/52 (40%) had an apnea-hypopnea > 5/h. Nocturnal found 25% participants associated ppFEV1 (p = 0.014), awake oxygen saturation (SpO2; p 0.021) partial pressure (pO2; 0.003); there no significant differences age, lung BMI for versus without OSA (all 0.05). Eight (15%) ESS score 10 (indicating EDS). best by pO2 (area under curve [AUC] 0.66, 0.048), while (AUC 0.74, 0.009), 0.76, 0.006) SpO2 0.71; 0.025).OSA, pwCF, but strong predictors identified. Therefore, we suggest regular PSG scoring regardless disease severity.