Obstructive sleep apnea and nocturnal hypoxemia in adult patients with cystic fibrosis

Adult Adolescent Cystic Fibrosis Medizinische Fakultät » Universitätsklinikum Essen » Ruhrlandklinik Essen – Universitätsklinik Polysomnography Medizin 610 Disorders of Excessive Somnolence Cystic fibrosis Diseases of the respiratory system Young Adult 03 medical and health sciences 0302 clinical medicine 616 Adults Humans ddc:610 Cystic fibrosis -- Adults -- Polysomnography -- Excessive daytime sleepiness -- Apnea-hypopnea index -- Obstructive sleep apnea -- Nocturnal hypoxemia Child Hypoxia ddc:610 Sleep Apnea, Obstructive RC705-779 Excessive daytime sleepiness Research Obstructive sleep apnea 3. Good health Apnea-hypopnea index ScholarlyArticle
DOI: 10.1186/s12890-022-02243-0 Publication Date: 2022-11-28T04:30:16Z
ABSTRACT
Abstract Background Obstructive sleep apnea (OSA), nocturnal hypoxemia and excessive daytime sleepiness (EDS) are common comorbidities in people with cystic fibrosis (pwCF). Most of the data showing this originates from children and adolescents. The aim of this study was to collect data on sleep parameters, EDS and pulmonary function from a large cohort of adult pwCF. Methods Full overnight polysomnography (PSG) was performed. EDS was determined using the Epworth Sleepiness Scale (ESS). Demographic and clinical data (body mass index [BMI], pulmonary function, capillary blood gases) were collected. Results A total of 52 adult pwCF were included (mean age 30.7 ± 8.0 years, mean percent predicted forced expiratory volume in 1 s [ppFEV1] of 52.1 ± 14.8). Overall AHI was in the normal range (4.5 ± 4.0/h); 21/52 pwCF (40%) had an apnea-hypopnea index > 5/h. Nocturnal hypoxemia was found in 25% of participants and this was associated with ppFEV1 (p = 0.014), awake oxygen saturation (SpO2; p = 0.021) and awake partial pressure of oxygen (pO2; p = 0.003); there were no significant differences in age, lung function and BMI were found for pwCF with versus without OSA (all p > 0.05). Eight pwCF (15%) had an ESS score > 10 (indicating EDS). OSA was best predicted by awake pO2 (area under the curve [AUC] 0.66, p = 0.048), while nocturnal hypoxemia was best predicted by ppFEV1 (AUC 0.74, p = 0.009), awake pO2 (AUC 0.76, p = 0.006) and awake SpO2 (AUC 0.71; p = 0.025). Conclusion OSA, nocturnal hypoxemia and EDS were common in adult pwCF, but no strong predictors were identified. Therefore, we suggest regular PSG and ESS scoring in adult pwCF, regardless of disease severity.
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