Obstructive sleep apnea and nocturnal hypoxemia in adult patients with cystic fibrosis
Adult
Adolescent
Cystic Fibrosis
Medizinische Fakultät » Universitätsklinikum Essen » Ruhrlandklinik Essen – Universitätsklinik
Polysomnography
Medizin
610
Disorders of Excessive Somnolence
Cystic fibrosis
Diseases of the respiratory system
Young Adult
03 medical and health sciences
0302 clinical medicine
616
Adults
Humans
ddc:610
Cystic fibrosis -- Adults -- Polysomnography -- Excessive daytime sleepiness -- Apnea-hypopnea index -- Obstructive sleep apnea -- Nocturnal hypoxemia
Child
Hypoxia
ddc:610
Sleep Apnea, Obstructive
RC705-779
Excessive daytime sleepiness
Research
Obstructive sleep apnea
3. Good health
Apnea-hypopnea index
ScholarlyArticle
DOI:
10.1186/s12890-022-02243-0
Publication Date:
2022-11-28T04:30:16Z
AUTHORS (11)
ABSTRACT
Abstract
Background
Obstructive sleep apnea (OSA), nocturnal hypoxemia and excessive daytime sleepiness (EDS) are common comorbidities in people with cystic fibrosis (pwCF). Most of the data showing this originates from children and adolescents. The aim of this study was to collect data on sleep parameters, EDS and pulmonary function from a large cohort of adult pwCF.
Methods
Full overnight polysomnography (PSG) was performed. EDS was determined using the Epworth Sleepiness Scale (ESS). Demographic and clinical data (body mass index [BMI], pulmonary function, capillary blood gases) were collected.
Results
A total of 52 adult pwCF were included (mean age 30.7 ± 8.0 years, mean percent predicted forced expiratory volume in 1 s [ppFEV1] of 52.1 ± 14.8). Overall AHI was in the normal range (4.5 ± 4.0/h); 21/52 pwCF (40%) had an apnea-hypopnea index > 5/h. Nocturnal hypoxemia was found in 25% of participants and this was associated with ppFEV1 (p = 0.014), awake oxygen saturation (SpO2; p = 0.021) and awake partial pressure of oxygen (pO2; p = 0.003); there were no significant differences in age, lung function and BMI were found for pwCF with versus without OSA (all p > 0.05). Eight pwCF (15%) had an ESS score > 10 (indicating EDS). OSA was best predicted by awake pO2 (area under the curve [AUC] 0.66, p = 0.048), while nocturnal hypoxemia was best predicted by ppFEV1 (AUC 0.74, p = 0.009), awake pO2 (AUC 0.76, p = 0.006) and awake SpO2 (AUC 0.71; p = 0.025).
Conclusion
OSA, nocturnal hypoxemia and EDS were common in adult pwCF, but no strong predictors were identified. Therefore, we suggest regular PSG and ESS scoring in adult pwCF, regardless of disease severity.
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