A dose response analysis of a specific bone marrow concentrate treatment protocol for knee osteoarthritis

• DOI: 10.1186/s12891-015-0714-z
• Publication Date: 2015-09-18T08:36:02Z
• Authors: Christopher J. Ce...; Hasan Al-Sayegh; Jamil Bashir; Shaun Goodyear; Michael D. Freeman
• Keywords: Knee pain; Sports medicine

Prior studies describing the treatment of symptomatic knee osteoarthritis with injections bone marrow concentrate have provided encouraging results. The relationship between cellular dose contained within and efficacy treatment, however, is unclear. In present study we describe clinical outcomes for in relation to higher lower cell concentrations a protocol. Data from an ongoing patient registry was culled identify 373 patients that received 424 osteoarthritic joints. scales these were assessed at baseline then tracked post-procedure 1, 3, 6 12 months, annually thereafter. Tracked included numeric pain scale; extremity functional questionnaire; International Knee Documentation Committee subjective improvement rating scale. Using outcome measures, receiver operating characteristic analysis used define optimal threshold which nucleated count could be divided into either or group groups defined using 4 × 108 cells. There 224 185 joints treated (≤4 108) (>4 respectively. Most diagnosed early stage osteoarthritis. Both demonstrated significant positive results all metrics. reported post scale values, comparison (1.6 vs. 3.2; P < 0.001). No differences detected other metrics, however. Improved function reduced observed protocol regardless dose; receiving concentration cells better group. These preliminary findings suggest may important factor governing autologous Further larger population help elucidate findings.