Tranexamic acid may benefit patients undergoing total hip/knee arthroplasty because of haemophilia

• DOI: 10.1186/s12891-019-2767-x
• Publication Date: 2019-09-04T01:18:28Z
• Authors: Ze Yu Huang; Qiang Huang; Han Jiang Zeng; Jun Ma; Bin Shen; Zong Ke Zhou; Fu Xing Pei
• Keywords: Joint replacement; Blood management; Sports medicine

The lower limb joints, including hip and knee, are the most commonly involved joints in haemophilic arthropathy. With a higher risk of transfusion, total knee arthroplasty (THA TKA) still first choice after failure conservative treatment. In present study, we aimed to analyze clinical outcomes complications rate joint limbs using tranexamic acid (TXA) or not.Thirty-four patients with haemophilia A undergoing 24 TKA 18 THA were evaluated this retrospective study (No. 201302009). Based on TXA not, they divided into either (12 knees 10 hips) Non-TXA groups 8 hips). Total blood loss, intraoperative amount FVIII usage, range motion, inflammatory biomarkers, function, pain status, complication patient satisfaction assessed compared at mean follow-up 68 months.Usage can decrease not only perioperative loss (p = 0.001), transfusion 0.017) supplemental < 0.001) but also swelling ratio, surgical pain. Moreover, non-TXA group, group had level biomarkers better function.The hemophiliacs treated less hidden rate, ratio postoperative swelling, pain, levels function. Further studies need performing assess long-term effects these patients.