Different diagnostic performance of plasma fibrinogen and D-dimer in periprosthetic joint infection: a propensity score matched study

• DOI: 10.1186/s12891-021-04282-w
• Publication Date: 2021-05-07T16:03:05Z
• Authors: Xi Chen; Wenwei Qian; Xisheng Weng; Jin Lin; Jin Jin; Yiou Wang; Shibai Zhu
• Keywords: Erythrocyte sedimentation rate; D-dimer

Abstract Background Fibrinogen (Fbg) and D-dimer have been used as biomarkers for the diagnosis of periprosthetic joint infection (PJI). However, previous research has reported conflicting results on diagnostic value in comparison to Fbg, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR). Aim This study aimed to: (1) determine optimal threshold plasma Fbg PJI compare their that CRP ESR; (2) investigate whether perform differently than ESR indicators different types PJI. Methods A total 115 revision cases after hip arthroplasty (THA) knee (TKA) were identified. Based demographic characteristics, 25 culture-positive matched 50 culture-negative using propensity score matching. Sensitivity, specificity, receiver operating characteristics (ROC), negative predictive (NPV), positive (PPV) calculated compared. Results The thresholds 2.72 mg/L D-dimer, 3.655 g/L 12.64 CRP, 27 mm/h ESR. Levels significantly higher group group. showed sensitivity 0.92, 0.56, 0.88, respectively, specificity 0.84, 0.96, 0.94, 0.80, respectively. ROC curve highest area under (AUC) (0.94), followed by (0.90), (0.87), (0.81). Conclusions Plasma exhibited a similar performance compared predicting high but low sensitivity. In our study, did not show better with pathogens Further studies are required difference between serum population.