Hyaluronic acid-carboxymethylcellulose reduced postoperative bowel adhesions following laparoscopic urologic pelvic surgery: a prospective, randomized, controlled, single-blind study

• DOI: 10.1186/s12894-016-0149-3
• Publication Date: 2016-06-10T12:00:49Z
• Authors: U-Syn Ha; Jun Sung Koh; Kang Jun Cho; Byung Il Yoon; Kyu Won Lee; Sung Hoo Hong; Ji Youl Lee
• Keywords: Laparoscopic radical prostatectomy; Clinical endpoint

To assess the anti-adhesive effect of treatment with hyaluronic acid-carboxymethylcellulose following laparoscopic radical prostatectomy. This was a randomized, controlled, single-blind, parallel-group study using in patients who underwent Sixty were enrolled study. All randomly assigned to either group (n = 30) or control 30). Viscera slide ultrasounds and plain X-rays obtained at enrollment (V0), postoperative week 12 (V1), 24 (V2). The primary end point difference excursion distance viscera ultrasound between V0 V2. A total 50 completed this average V2 experimental 25) significantly longer than 25, 2.7 ± 1.2 vs. 1.3 1.0 cm, respectively; p < 0.001). differences distances higher (1.48 1.5 2.9 None showed adverse events associated use acid-carboxymethylcellulose. randomized demonstrated that resulted reduction bowel adhesion abdominal wall after pelvic surgery had good clinical safety. ClinicalTrials.gov Identifier: NCT02773251 Date: May 12, 2016.