A follow-up study on factors affecting the recovery of patients with hypothyroidism in different selenium environments

• DOI: 10.1186/s12902-024-01536-1
• Publication Date: 2024-01-29T04:42:11Z
• Authors: Si Wang; Ping Chen; Yayi He; Jing Wei; Li Tian; Yajun Wu; Hongjun Lv; Xiaogang Peng; Xingru Zhang; Bingyin Shi; Qian Wu
• Keywords: Univariate analysis; Thyroid disease

Abstract Background Hypothyroidism is a major manifestation of autoimmune thyroid diseases (AITD). We previously reported that low selenium (Se) status was linked to an elevated prevalence diseases. hypothesized Se may also influence the restoration function. Thus, this study aimed investigate factors affecting recovery function in patients with (sub-)clinical hypothyroidism, specific focus on status. Methods conducted 6-year prospective cohort comparing two counties different concentrations. Demographic and disease data were collected from 1,190 individuals (549 Se-adequate 641 Se-deficient) who completed follow-up 2019. In addition, urinary iodine ( I ) levels, function, serum nail levels measured. Logistic regression used relationship between deficiency Results Sex smoking similar studied. Thyroid rate significantly higher Se-deficient (46.0% vs. 30.6%, P = 0.008). multivariate analysis, our results show female sex (odds ratio [OR] (95% confidence interval [CI]) 1.875 (1.080–3.257), 0.026] increasing age [OR (95%CI) 1.028(1.007–1.049), 0.009] associated rate. Additionally, revealed while significant univariate association appeared disappear analysis. Conclusions Female have unfavorable effects over 30 years (sub-) clinical hypothyroidism.