The association between estimated glucose disposal rate and metabolic dysfunction-associated steatotic liver disease and liver fibrosis in US adults

• DOI: 10.1186/s12902-025-01891-7
• Publication Date: 2025-03-11T03:39:33Z
• Authors: Wanqian Liu; Xiaozhong Li; Ling Chen; Xiao Luo
• Keywords: Liver disease

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic disease, also considered a metabolic syndrome, and associated with poor prognosis. eGDR (estimated glucose disposal rate) new biomarker to assessment insulin resistance (IR). The association between MASLD fibrosis currently unclear. aim of this cross-sectional study appraise fibrosis. This have enrolled 3,100 participants from 2017–2018 National Health Nutrition Examination Surveys (NHANES). Binary logistic regression analysis was used assess Receiver operating characteristic (ROC) applied estimate ability identify MASLD. mean age subjects 54.59 (17.29) years, 49.26% were female. prevalence 62.19% 11.15%, respectively. In fully adjusted models, there negative associations controlled attenuation parameter (CAP) stiffness measurement (LSM), βs -15.18 − 0.74 (all p < 0.01), There fibrosis, odds ratios (ORs) 95% confidence intervals 0.53 (95% CI: 0.48–0.74) 0.40 0.28–0.57) 0.01). area under curve (AUC) for identifying 0.75, findings suggest significant as well may serve