Polymorphic variants in genes related to stress coping are associated with the awake bruxism

• DOI: 10.1186/s12903-021-01844-1
• Publication Date: 2021-10-05T15:39:36Z
• Authors: Zofia Maciejewska...; Marta Kaczmarek-Ryś; Szymon Hryhorowicz; Agnieszka Przysta...; Tomasz Gredes; Barbara Maciejewska; Justyna Hoppe-Goł...; Ryszard Słomski; Andrzej Pławski; Agata Czajka-Jaku...
• Keywords: Etiology

Abstract Background Chronic stress is one of the leading predisposing factors in bruxism aetiology, but influence genetic also suggested. We aimed to study whether sequence variants genes involved regulation pathways: NTRK2 and BDNF , may be associated with awake susceptibility, clinical presentation, patients’ perceived level. Methods The group included 104 patients probable 191 population controls. Patients underwent dental examination concerning symptoms psychological testing. Genotyping was performed using HRMA sequencing. Statistical analyses were conducted, P values below 0.05 considered statistically significant. Results observed a positive correlation measured level pathological teeth attrition anterior segment (r = 0.45, < 0.001), enamel attritions 0.44, tongue impressions 0.50, 0.001) posterior 0.27, 0.005). Moreover, c.196A variant (p.66Met) gene c.1397-31392G allele present elevated frequency, comparing Conclusions This hence thesis that substantial contributing factor occurrence its manifestations. related coping correlated bruxism’s susceptibility via