Clinical and microbiological efficacy of intra-pocket application of diode laser in grade C periodontitis: a randomized controlled clinical trial

• DOI: 10.1186/s12903-024-04031-0
• Publication Date: 2024-02-23T13:02:29Z
• Authors: Souzy Kamal Anwar; Amira Mohamed Hafez; Yara Safwat Roshdy
• Keywords: Aggregatibacter actinomycetemcomitans; Clinical attachment loss

Abstract Background Periodontitis is a microbially induced disease destroying structures anchoring teeth to jaw bones. Although metronidazole in combination with spiramycin the effective conventional treatment of stage III grade C periodontitis, it has several systemic side effects. Laser therapy widely used nowadays as an adjunct scaling and root planing (SRP) modulate inflammatory host response eradicate microbes, due bactericidal detoxifying Since microbiological analysis one diagnostic methods identifying periodontal risk; our research aimed investigate efficacy intra-pocket application diode laser (980 nm) versus antibiotic enhancing clinical parameters periodontitis. Methods A randomized controlled trial was conducted on fifty patients divided equally into two groups. We managed test group by SRP control administration (spiramycin metronidazole). Then, we measured pocket depth (PPD) attachment loss (CAL) for both groups, before (baseline), four twelve weeks after. Moreover, collected gingival crevicular fluid from groups at baseline, after analyzed real-time polymerase chain reaction detect relative count Aggregatibacter actinomycetemcomitans Porhyromonas gingivalis. Results Compared all assessed attested improvement end study period each individually no significant difference between studied Although, weeks, flare up bacterial levels detected administration. Conclusion can be considered modality avoiding effects solving recurrence problems resistance long term usage. Trial registration NCT05222737 retrospectively 03/02/2022, Clinicaltrial.gov.