Chronic nonspecific cheilitis associated with tislelizumab treatment in a patient with a history of tongue squamous cell carcinoma: a case report

• DOI: 10.1186/s12903-024-04683-y
• Publication Date: 2024-08-07T14:03:01Z
• Authors: Haiyue Yu; Qiao Ruan; Liyi Jiang
• Keywords: Male; Multidisciplinary approach; Chronic nonspecific cheilitis; RK1-715; Case Report; Middle Aged; Antibodies, Monoclonal, Humanized; Tongue Neoplasms; Tislelizumab; 03 medical and health sciences; 0302 clinical medicine; Cheilitis; Candidiasis, Oral; Dentistry; Chronic Disease; Carcinoma, Squamous Cell; Humans; Female; Immunotherapy; Oral manifestations

Chronic nonspecific cheilitis is a complex condition characterized by persistent lip peeling and discomfort. This case report explores the clinical progression of a patient with history of tongue squamous cell carcinoma and subsequent Tislelizumab treatment, presenting with persistent lip peeling.A patient with a history of tongue squamous cell carcinoma (T2N0M0), treated with chemotherapy, surgery, and Tislelizumab, presented with six months of persistent lip peeling. Clinical examination revealed distinct features of chronic nonspecific cheilitis with infectious angular cheilitis (Oral Candidiasis). A tailored treatment plan, emphasizing oral hygiene practices and local treatments with Sodium Bicarbonate, Tacrolimus ointment, and Chlortetracycline ointment. Follow-up visits demonstrated sustained improvement, highlighting the significance of individualized approaches.This case underscores the importance of recognizing and managing oral manifestations in patients with a history of cancer and immunotherapy. The patient's response to treatment suggests that a multifaceted approach, combining local therapy with lifestyle modifications, can be effective in managing chronic nonspecific cheilitis associated with immunotherapy. Routine follow-up appointments, guided by personalized medicine principles, contribute to sustained patient well-being.