Number of parity is associated with low-grade albuminuria in middle-aged and elderly Chinese women

• DOI: 10.1186/s12905-019-0814-2
• Publication Date: 2019-10-07T12:02:54Z
• Authors: Kan Sun; Diaozhu Lin; Feng Qiling; Feng Li; Yiqin Qi; Wanting Feng; Meng Ren; Li Yan; Dan Liu
• Keywords: Albuminuria

Abstract Background Women with a higher number of pregnancies have risk developing cardiovascular diseases. Subtle fluctuations in albumin excretion could be related to pathophysiologic changes the vascular system. We aimed investigate possible association parity low-grade albuminuria. Methods conducted community-based study 6495 women aged 40 years or older. Low-grade albuminuria was defined according highest quartile urine albumin-to-creatinine ratio participants free micro- macro-albuminuria. Results Parous had increased age, body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), fasting plasma glucose (FPG), and insulin, as well decreased high-density lipoprotein cholesterol (HDL-C), estimated glomerular filtration rate (eGFR) levels, proportion menopause. The prevalence parous gradually number. Compared one childbirth, those more than two childbirths were independently associated prevalent (odds ratios [ORs] 1.41, 95% confidence interval [CI], 1.09–1.81) after multiple adjustments. In subgroup analysis adjustments, significant relation between detected subjects age 55 Conclusion Number is middle-aged elderly Chinese without