Effect of a short-term vitamin E supplementation on oxidative stress in infertile PCOS women under ovulation induction: a retrospective cohort study

• DOI: 10.1186/s12905-020-00930-w
• Publication Date: 2020-04-06T17:03:28Z
• Authors: Jie Chen; Qian Guo; Ying-hao Pei; Qing-ling Ren; Lei Chi; Rong-kui Hu; Yong Tan
• Keywords: Adult; Ovulation induction; Gynecology and obstetrics; Fertility Agents, Female; Clomiphene; 3. Good health; Oxidative Stress; 03 medical and health sciences; 0302 clinical medicine; Ovulation Induction; Pregnancy; Infertility; Dietary Supplements; RG1-991; Humans; Vitamin E; Female; Public aspects of medicine; RA1-1270; Infertility, Female; Polycystic ovary syndrome; Research Article; Polycystic Ovary Syndrome; Retrospective Studies

Abstract Background Vitamin E, which is critically important in the whole process of reproduction, can antagonize oxidative stress caused by oxygen free radicals and antioxidant imbalance regulate normal physiological function reproductive system. The effect short-term supplementation vitamin E on outcomes infertile women with polycystic ovary syndrome (PCOS) when they underwent ovulation induction clomiphene citrate (CC) human menopausal gonadotropin (HMG) remains unknown. Methods This was a retrospective cohort clinical trial from October 2015 to April 2017. A total 321 PCOS cases CC HMG. Patients group ( n = 110) did not receive while patients B 105) C 106) received oral treatment at 100 mg/day during follicular phase luteal phase, respectively. Results It observed no significant differences rate, pregnancy ongoing rate among three groups. interesting that dosage HMG were lower compared those (P<0.05). Conclusions improve stress, reduce exogenous economic cost similar cycle. However, does alter Trial registration ChiCTR-OOC-14005389 , 2014.