Can the dynamic spectral imaging (DSI) color map improve colposcopy examination for precancerous cervical lesions? A prospective evaluation of the DSI color map in a multi-biopsy clinical setting

• DOI: 10.1186/s12905-020-01169-1
• Publication Date: 2021-01-12T12:12:36Z
• Authors: Berit Bargum Booth; Lone Kjeld Petersen; Jan Blaakaer; Tonje Johansen; Henrik Mertz; Katja Dahl; Pinar Bor
• Keywords: Ascus (bryozoa)

Abstract Background Colposcopy serves as a subjective examination of the cervix with low sensitivity to detect cervical intraepithelial dysplasia (CIN) grade 2 or worse (CIN2 +). Dynamic spectral imaging (DSI) colposcopy has been developed provide an objective element examinations and proven increase detecting CIN2 + . We aimed assess performance DSI color map compared it histological diagnoses biopsies in determining CIN present. Methods Women were included consecutive, prospective manner at Randers Regional Hospital, Denmark. eligible participate if they referred for due abnormal smear (threshold: ≥ ASCUS) follow-up after previously diagnosed CIN. All women had four taken, one directed by colposcopists alone prior viewing map, worst on respective two additional biopsies. analyzed separately. calculated sensitivity, specificity, positive predictive values, negative values (NPVs) 95% confidence intervals (CIs). Results A total 800 recruited. Of these, 529 (66.1%) inclusion. The was found be 48.1% (95% CI 41.1–55.1) finding +) when diagnosis biopsy. This 42.5% 36.7–48.5) final all NPV 53.5% 50.5–56.5). Conclusion indicated might not consistently reflect true Thus, even though indicates low-grade changes, should still consider taking from area high-grade changes Trial registration : NCT04249856, January 31 2020 (retrospectively registered).