Biopsychosocial risk factors of depression during menopause transition in southeast China

• DOI: 10.1186/s12905-022-01710-4
• Publication Date: 2022-07-05T13:13:42Z
• Authors: Ketan Chu; Jing Shui; Linjuan Ma; Yizhou Huang; Fan Wu; Fang Wei; Xingjun Meng; Jie Luo; Fei Ruan; Jianhong Zhou
• Keywords: Depression; Underweight

Abstract Objective More than 2 billion women are experiencing menopause transition in China and some of them suffered from depression; while the risk factors depression during were still unclearin China. We aimed to investigate mid-life Southeast Method This study included 1748 Chinese aged 40–65 years-old who visited gynecology outpatient department Women’s hospital School Medicine, Zhejiang University 2010–2018. Demographic information was collected, modified Kupperman Menopausal Index (mKMI) Hamilton Rating Scale for Depression assessed. Circulating levels sex hormones tested. Ordinal logistic regression analysis performed identify depression. Results The prevalence symptoms 47.43%. majority had mild (38.56%) or moderate depressive (8.00%); only 0.86% severe symptoms. Compared with perimenopausal women, postmenopausal increased risks more associations between menopausal syndromes intensity strongly positive (OR 6.69, 95% CI 5.39–8.29). Elder age, higher follicle stimulating hormone levels, lower estradiol fewer parity positively related Among underweight, mKMI > 14, earlier age at menopause, shorter reproductive period, longer duration after incresed Conclusions results demonstrated a high proportion complaining menopause. In estrogen events associated Gynecological endocrinologists should consider screening high-risk women.