Anti-inflammatory and in-vitro antibacterial activities of Traditional Chinese Medicine Formula Qingdaisan

• DOI: 10.1186/s12906-016-1475-4
• Publication Date: 2016-12-05T08:15:02Z
• Authors: Xinghua Zhao; Xin He; Xiuhui Zhong
• Keywords: Anti-inflammatory

Qingdaisan (Formulated Indigo powder, QDS) are widely used for treatment of aphtha, sore throat and bleeding gums in China. The aim the study is to evaluate anti-inflammatory, antibacterial dental ulcer therapeutic effects QDS.Dimethylbenzene-induced ear edema test cotton pellet-induced granuloma were anti-inflammatory activities QDS on acute chronic inflammatory. healing time local pathologic changes assess ulcer. each component whole formulation determined by agar well diffusion assay. High-dose low-dose tested this experiment Gui Lin Watermelon Frost Powder (GLWFP) was as positive control.Oral with significantly accelerated ulcerative lesions induced phenol injury. ulcers high-dose group all healed within 6 days. It shorter than those GLWFP group. Less quantity inflammatory cells plenty fibroblasts observed pathological section groups. also exhibited significant activity both animal models. Although some components activities, didn't show any vitro.The showed that has obviously inflammatory, a remarkable effect caused phenol. have selected strains vitro.