Phytochemistry, antioxidant, anticancer, and acute toxicity of traditional medicinal food Biarum bovei (Kardeh)

• DOI: 10.1186/s12906-023-04080-y
• Publication Date: 2023-08-09T09:02:32Z
• Authors: Bassam Ali Abed W...; Zaenah Zuhair Alamri; Ahmed A.j. Jabbar; Ibrahim Abdel Azi...; Riyad A. Almaimani; Hussain A. Almasmoum; Mazen M. Ghaith; Wesam F. Farrash; Yahya A. Almutawif; Khalid Aidarous A...; Soliman Mohammed ...; Rahaf Frehan Alha...
• Keywords: Stigmasterol; Phytochemical; Phytochemistry; Nutraceutical; HeLa

The Biarum species (Kardeh) has been consumed as a traditional functional food and medicine for decades. current study investigates the phytochemistry, in-vitro in-vivo bioactivities of methanol extracts B. bovei.The Gas-chromatography mass spectrophotometer (GS/GS-MS) was used to analyze phytochemical profile bovei leaves corms. (BBE) were also investigated antioxidant, anticancer, acute toxicity (2000 mg/kg) activities.The chemical profiling BBE revealed mainly fatty acids, phytosterol, alcohols, hydrocarbon compounds. Namely, Linoleic acid, eliadic palmitic 22,23-dihydro-stigmasterol, campesterol. antioxidant activity ranged between 0.24-3.85 μg TE/mL based on different assays. exhibited significant anticancer against DU-145 (prostate cancer cells), MCF-7 (human breast adenocarcinoma), HeLa cervical cancer) cell lines with IC50 values ranging 22.73-44.24 μg/mL. Rats fed 2000 mg/kg dosage showed absence any toxicological sign or serum biochemical changes.The detected phytochemicals scientifically backup folkloric usage an important source nutraceuticals alternative oxidative stress-related diseases carcinogenesis inhibition.