Exploring the therapeutic impact of Salvia officinalis on lipid and oxidative stress markers in patients with polycystic ovary syndrome – a randomized placebo-controlled clinical trial

• DOI: 10.1186/s12906-025-04858-2
• Publication Date: 2025-03-26T07:27:48Z
• Authors: Arezoo Maleki-Haj...; Faraz Mojab; Fardin Amidi; Leila Amini
• Keywords: Salvia officinalis; Lipid Profile

Salvia.officinalis (S. officinalis), is recognized for its antihyperlipidemic, metabolism-regulating, and antioxidant properties in diabetic hyperlipidemic disorders. This study examining effects on lipid oxidative stress (OS) markers patients with Polycystic Ovary Syndrome (PCOS), thereby substantiating role managing metabolic In this randomized placebo-controlled trial was performed gynecology clinics affiliated to Iran University of Medical Sciences. Accordingly, 70 Iranian married women aged 15–40 years newly diagnosed PCOS were included. They receive either 330 mg S. officinalis extract or placebo daily eight weeks. The outcomes included profile OS markers. found a significantly lower triglyceride levels malondialdehyde after weeks intake compared placebo. Also, the mean change triglyceride, high-density lipoprotein cholesterol, malondialdehyde, total capacity statistically significant intervention group. demonstrates that can reduce PCOS, suggesting potential as an adjunctive natural therapy imbalances associated condition. While did not alter other markers, observed improvements highlight therapeutic promise officinalis. These findings support further investigation into clinical applications benefits health. IRCT201504146917N2 2015–10-03 (registered while recruiting).