An increase of phosphatidylcholines in follicular fluid implies attenuation of embryo quality on day 3 post-fertilization

• DOI: 10.1186/s12915-021-01118-w
• Publication Date: 2021-09-09T08:02:48Z
• Authors: Ju Wang; Wei Zheng; Shuoping Zhang; Keqiang Yan; Miao Jin; Huiling Hu; Zhen Ma; Fei Gong; Guangxiu Lu; Yan Ren; Liang Lin; Ge Lin; Liang Hu; Siqi Liu
• Keywords: Follicular fluid

Abstract Background Although oocyte quality is the dominant factor determining embryo quality, few studies have been conducted to evaluate based on metabolites related oocyte. With quantification of follicular fluid (FF) metabolites, in assisted reproductive technology (ART), this study sought or through an informative approach. Results An evaluation model consisting 17 features was generated distinguish day 3 post-fertilization, and phosphatidylcholines (PCs) were key contributors evaluation. The extended patients under different ages hyperstimulations, further enriched facilitate quality. clustered pathway analysis, leading a hypothesis that accumulation arachidonic acid induced by PCs might weaken post-fertilization. Conclusions A discriminating with metabolic elicited from established, which enabled even certain clinical conditions, increase implies attenuation