Ambient air pollution associated with incidence and dynamic progression of type 2 diabetes: a trajectory analysis of a population-based cohort

• DOI: 10.1186/s12916-022-02573-0
• Publication Date: 2022-10-31T01:02:19Z
• Authors: Yinglin Wu; Shiyu Zhang; Samantha E. Qian; Miao Cai; Haitao Li; Chongjian Wang; Hongtao Zou; Lan Chen; Michael G. Vaughn; Stephen Edward Mc...; Hualiang Lin
• Keywords: Air Pollutants; Incidence; Air pollution; R; Type 2 diabetes; Multi-state model; Environmental Exposure; Diabetes complication; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Diabetes Mellitus, Type 2; 13. Climate action; Air Pollution; 11. Sustainability; Medicine; Humans; Diabetes mortality; Particulate Matter; Research Article

Though the association between air pollution and incident type 2 diabetes (T2D) has been well documented, evidence on with development of subsequent complications post-diabetes mortality is scarce. We investigate whether associated different progressions outcomes T2D.Based UK Biobank, 398,993 participants free diabetes-related events at recruitment were included in this analysis. Exposures to particulate matter a diameter ≤ 10 μm (PM10), PM2.5, nitrogen oxides (NOx), NO2 for each transition stage estimated participant's residential addresses using data from UK's Department Environment, Food Rural Affairs. The T2D, (diabetic kidney disease, diabetic eye neuropathy peripheral vascular cardiovascular events, metabolic events), all-cause mortality, cause-specific mortality. Multi-state model was used analyze impact T2D. Cumulative probabilities stages T2D under levels estimated.During 12-year follow-up, 13,393 patients identified, whom, 3791 developed 1335 died. observed that progression magnitudes. In multivariate model, hazard ratios [95% confidence interval (CI)] per interquartile range elevation PM2.5 1.63 (1.59, 1.67) 1.08 (1.03, 1.13) transitions healthy complications, 1.50 (1.47, 1.53), 1.49 (1.36, 1.64), 1.54 (1.35, 1.76) risk baseline, respectively. Generally, we stronger estimates four pollutants baseline than those other transitions. Moreover, found significant associations due cancer diseases or complications. cumulative probability generally higher among exposure.This study indicates ambient exposure may contribute increased incidence but diverse extents progressions.