Association of lipid, inflammatory, and metabolic biomarkers with age at onset for incident cardiovascular disease

• DOI: 10.1186/s12916-022-02592-x
• Publication Date: 2022-11-10T01:02:32Z
• Authors: Xue Tian; Shuohua Chen; Yingting Zuo; Yijun Zhang; Xiaoli Zhang; Qin Xu; Yanxia Luo; Shouling Wu; Anxin Wang
• Keywords: Dyslipidemia

Abstract Background Risk profiles for premature cardiovascular disease (CVD) are unclear. This study aimed to examine baseline risk incident CVD by age at onset in Chinese population. Methods A total of 97,841 participants without were enrolled from the Kailuan cohort study. Four groups examined (< 55, 55 < 65, 65 75, and ≥ 75 years) onset. included clinical, lipid, metabolic, inflammatory factors biomarkers. Results Of clinical factors, diabetes was associated with highest relative younger than years (sub-distributional hazard ratio [sHR], 4.08; 95% confidence interval [CI], 3.47–4.80). that also noted hypertension, metabolism syndrome, overweight or obese, dyslipidemia, smoking. Among biomarkers, insulin resistance measured triglyceride-glucose index had sHR (1.42; CI, 1.35–1.49) years. In comparison, weaker but significant associations most lipids, metabolic Most biomarkers attenuated increasing Some similar association, while a few no association any age. Conclusions These findings showed resistance, addition smoking, appeared be strongest CVD, rates older ages.