In vitro susceptibility of four antimicrobials against Riemerella anatipestifer isolates: a comparison of minimum inhibitory concentrations and mutant prevention concentrations for ceftiofur, cefquinome, florfenicol, and tilmicosin

• DOI: 10.1186/s12917-016-0796-3
• Publication Date: 2016-11-09T18:17:53Z
• Authors: Yafei Li; Yanan Zhang; Huanzhong Ding; Xian Mei; Wei Liu; Jiaxiong Zeng; Zhenling Zeng
• Keywords: Florfenicol; Ceftiofur; Tilmicosin

Mutant prevention concentration (MPC) is an alternative pharmacodynamic parameter that has been used to measure antimicrobial activity and represents the propensities of agents select resistant mutants. The range between minimum inhibitory (MIC) MPC defined as mutant selection window (MSW). MSW parameters represent ability inhibit bacterial mutants selected. This study was conducted determine MIC values four antimicrobials including ceftiofur, cefquinome, florfenicol tilmicosin against 105 Riemerella anatipestifer isolates.The MIC50/MIC90 clinical isolates tested in our for were 0.063/0.5、0.031/0.5、1/4、1/4 μg/mL, respectively; MPC50/ MPC90 4/64、8/64、4/32、16/256 respectively. These results provided information on use these compounds treating R. infection; however, additional studies are needed demonstrate their therapeutic efficacy.Based theory, hierarchy with respect selecting subpopulations follows: cefquinome > ceftiofur florfenicol. Cefquinome drug presented highest risk among agents.